使用赛拉嗪对牛进行尾骶部硬膜外镇痛
Caudal epidural analgesia in cattle using xylazine.
作者信息
Caron J P, LeBlanc P H
机构信息
Connaught Laboratories Limited, Willowdale, Ontario.
出版信息
Can J Vet Res. 1989 Oct;53(4):486-9.
Each of 25 mature Holstein cows were given a single 5 mL epidural injection of one of four different concentrations of xylazine or saline. The onset, magnitude and duration of caudal epidural analgesia was quantitated with the use of a low voltage DC current applied to the perineal area. The dose that produced the longest duration of analgesia and produced the least ataxia or sedation was approximately 0.05 mg/kg (25 mg in 5 mL diluent). The analgesia produced by this xylazine dose was compared to a standard dose of epidural lidocaine (100 mg/5 mL) by the same method. To investigate the role of systemic absorption in the production of epidural analgesia, the previously utilized epidural xylazine dosage was given intramuscularly to four adult cows. Analgesia was quantitated as before and the results compared with epidural xylazine. Epidural xylazine produced a significantly greater duration of analgesia, as measured by this model, than did epidural lidocaine. Xylazine, given epidurally, produced greater perineal analgesia than did xylazine given intramuscularly.
对25头成年荷斯坦奶牛中的每一头，均进行一次5毫升的硬膜外注射，注射的是四种不同浓度的赛拉嗪或生理盐水之一。通过对会阴区域施加低电压直流电，对尾段硬膜外镇痛的起效时间、程度和持续时间进行定量。产生最长镇痛持续时间且引起最少共济失调或镇静作用的剂量约为0.05毫克/千克（在5毫升稀释液中为25毫克）。通过相同方法，将该赛拉嗪剂量产生的镇痛效果与标准剂量的硬膜外利多卡因（100毫克/5毫升）产生的镇痛效果进行比较。为研究全身吸收在硬膜外镇痛产生中的作用，将之前使用的硬膜外赛拉嗪剂量给4头成年奶牛进行肌肉注射。镇痛效果如前所述进行定量，并将结果与硬膜外注射赛拉嗪的结果进行比较。通过该模型测量，硬膜外注射赛拉嗪产生的镇痛持续时间明显长于硬膜外注射利多卡因。硬膜外注射赛拉嗪产生的会阴镇痛效果比肌肉注射赛拉嗪产生的效果更好。
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