印度中部比尔部落人群15个常染色体短串联重复序列位点的基因变异
Genetic variation at 15 autosomal STR loci in Bhil tribal population of Central India.
作者信息
Shrivastava Pankaj, Jain Toshi, Gupta Umang, Trivedi Veena Ben
机构信息
a DNA Fingerprinting Unit, State Forensic Science Laboratory, Department of Home (Police) , Government of Madhya Pradesh , Sagar, MP , India.
出版信息
Ann Hum Biol. 2016;43(1):81-4. doi: 10.3109/03014460.2015.1014419. Epub 2015 Apr 24.
AIMS
Genotypic polymorphism studies at 15 highly polymorphic short tandem repeat (STR) loci were carried out in Bhil tribal population of Madhya Pradesh, in central region of India.
METHODS
The analysis of 15 autosomal STR loci (TH01, D3S1358, vWA, D21S11, TPOX, D7S820, D19S433, D5S818, D2S1338, D16S539, CSF1PO, D13S317, FGA, D18S51, D8S1179) was done in 183 unrelated individuals of the Bhil tribe.
RESULTS
Heterozygosity among the studied 15 autosomal STR loci ranged from 63.5-86.5%. The loci D2S1338 and FGA were found to be mostly polymorphic. All loci fall under Hardy-Weinberg equilibrium, except loci D18S51 and D7S820. These STR loci were highly informative and discriminating, with CPD > 0.99999.
CONCLUSION
The clustering pattern of the NJ tree and the PCA plot showed grouping of the Bhil population with previously reported tribes of central India.
目的
在印度中部中央邦的比尔部落人群中，对15个高度多态性短串联重复序列（STR）位点进行基因多态性研究。
方法
对183名无关的比尔部落个体进行了15个常染色体STR位点（TH01、D3S1358、vWA、D21S11、TPOX、D7S820、D19S433、D5S818、D2S1338、D16S539、CSF1PO、D13S317、FGA、D18S51、D8S1179）的分析。
结果
所研究的15个常染色体STR位点的杂合度范围为63.5 - 86.5%。发现位点D2S1338和FGA多态性最高。除位点D18S51和D7S820外，所有位点均符合哈迪-温伯格平衡。这些STR位点具有高度信息性和鉴别力，累积个体识别率（CPD）> 0.99999。
结论
邻接树和主成分分析图的聚类模式显示，比尔人群与印度中部先前报道的部落聚类在一起。
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