食管鳞状细胞癌中的癌症干细胞：鉴定、预后及治疗前景
Cancer stem cells in oesophageal squamous cell carcinoma: Identification, prognostic and treatment perspectives.
作者信息
Islam Farhadul, Gopalan Vinod, Wahab Riajul, Smith Robert A, Lam Alfred K-Y
机构信息
Cancer Molecular Pathology, School of Medicine and Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland, Australia.
Cancer Molecular Pathology, School of Medicine and Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland, Australia.
出版信息
Crit Rev Oncol Hematol. 2015 Oct;96(1):9-19. doi: 10.1016/j.critrevonc.2015.04.007. Epub 2015 Apr 16.
Cancer stem cells (CSCs) are a vital subpopulation of cells to target for the treatment of cancers. In oesophageal squamous cell carcinoma (ESCC), there are several markers such as CD44, ALDH, Pygo2, MAML1, Twist1, Musashi1, Side population (SP), CD271 and CD90 that have been proposed to identify the cancer stem cells in individual cancer masses. It has also been demonstrated that stem cell markers like ALDH1, HIWI, Oct3/4, ABCG2, SOX2, SALL4, BMI-1, NANOG, CD133 and podoplanin are associated with patient's prognosis, pathological stages, cancer recurrence and therapy resistance. Finding new cancer stem cell targets or designing drugs to manipulate the known molecular targets in CSCs could be useful for improvements in clinical outcomes of the disease. To conclude, data suggest that CSCs in oesophageal squamous cell carcinoma are related to resistance to therapy and poor prognosis of patients with ESCC. Therefore, innovative insights into CSC biology and CSC-targeted therapies will help to achieve more effective management of patients with oesophageal squamous cell carcinoma.
癌症干细胞（CSCs）是癌症治疗中至关重要的细胞亚群。在食管鳞状细胞癌（ESCC）中，有多种标志物，如CD44、醛脱氢酶（ALDH）、Pygo2、MAML1、Twist1、Musashi1、侧群细胞（SP）、CD271和CD90，已被提出用于识别单个癌块中的癌症干细胞。研究还表明，像ALDH1、HIWI、Oct3/4、ABCG2、SOX2、SALL4、BMI-1、NANOG、CD133和血小板内皮细胞黏附分子（podoplanin）等干细胞标志物与患者的预后、病理分期、癌症复发及治疗耐药性相关。寻找新的癌症干细胞靶点或设计药物来调控癌症干细胞中已知的分子靶点，可能有助于改善该疾病的临床治疗效果。总之，数据表明食管鳞状细胞癌中的癌症干细胞与治疗耐药性及ESCC患者的不良预后有关。因此，对癌症干细胞生物学及针对癌症干细胞的治疗方法的创新性见解，将有助于实现对食管鳞状细胞癌患者更有效的管理。
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