The Relationship Between and Inflammatory Bowel Disease.

BACKGROUND

may have a protective effect against inflammatory bowel disease (IBD). We integrated epidemiological data to identify the correlation between IBD and . Moreover, we analyzed whether IBD medication and classification affect , and whether eradication of leads to recurrence of IBD.

METHODS

Articles published up to May 1, 2019, in three main databases including PubMed, MEDLINE and Embase, were searched. Study types included cross-sectional studies, retrospective studies and perspective studies, and data were combined and analyzed. Spearman correlation analysis and meta-analysis were performed after collecting and collating the relevant data. Sensitivity analysis and meta-regression were used to evaluate reliability and heterogeneity.

RESULTS

Fifty-nine studies on IBD prevalence, 127 studies on prevalence, and 23 studies for meta-analysis were included. IBD, ulcerative colitis (UC) and Crohn's disease (CD) were negatively correlated to prevalence (all <0.001). The meta-analysis results showed that compared to controls, the odds of having infection were 0.44, 0.36, 0.54 for IBD, CD and UC, respectively (OR=0.44, 95% CI=0.34-0.59; OR=0.36, 95% CI=0.26-0.49; OR=0.54, 95% CI=0.4-0.72). Moreover, IBD patients were 1.41 times (OR=1.41, 95% CI=1.25-1.58) more likely to relapse after eradication of . Finally, infection was not related to IBD medication and classification.

CONCLUSION

prevalence was negatively correlated to IBD and had a protective effect against IBD. Furthermore, eradication of can lead to recurrence of IBD.