Department of Gastroenterology, The First People's Hospital of Wenling, Wenling, Zhejiang, China.
Taizhou Cancer Hospital, Wenzhou Medical University, Wenling, Zhejiang, China.
Arch Iran Med. 2021 Apr 1;24(4):317-325. doi: 10.34172/aim.2021.44.
may have a protective effect against inflammatory bowel disease (IBD). We integrated epidemiological data to identify the correlation between IBD and . Moreover, we analyzed whether IBD medication and classification affect , and whether eradication of leads to recurrence of IBD.
Articles published up to May 1, 2019, in three main databases including PubMed, MEDLINE and Embase, were searched. Study types included cross-sectional studies, retrospective studies and perspective studies, and data were combined and analyzed. Spearman correlation analysis and meta-analysis were performed after collecting and collating the relevant data. Sensitivity analysis and meta-regression were used to evaluate reliability and heterogeneity.
Fifty-nine studies on IBD prevalence, 127 studies on prevalence, and 23 studies for meta-analysis were included. IBD, ulcerative colitis (UC) and Crohn's disease (CD) were negatively correlated to prevalence (all <0.001). The meta-analysis results showed that compared to controls, the odds of having infection were 0.44, 0.36, 0.54 for IBD, CD and UC, respectively (OR=0.44, 95% CI=0.34-0.59; OR=0.36, 95% CI=0.26-0.49; OR=0.54, 95% CI=0.4-0.72). Moreover, IBD patients were 1.41 times (OR=1.41, 95% CI=1.25-1.58) more likely to relapse after eradication of . Finally, infection was not related to IBD medication and classification.
prevalence was negatively correlated to IBD and had a protective effect against IBD. Furthermore, eradication of can lead to recurrence of IBD.
可能对炎症性肠病（IBD）具有保护作用。我们整合了流行病学数据，以确定 IBD 与之间的相关性。此外，我们分析了 IBD 药物和分类是否会影响，以及是否根除会导致 IBD 复发。
检索了三个主要数据库（PubMed、MEDLINE 和 Embase）中截至 2019 年 5 月 1 日发表的文章。研究类型包括横断面研究、回顾性研究和前瞻性研究，并对数据进行了合并和分析。在收集和整理相关数据后，进行了 Spearman 相关性分析和荟萃分析。使用敏感性分析和荟萃回归评估可靠性和异质性。
纳入了 59 项关于 IBD 患病率的研究、127 项关于 患病率的研究和 23 项荟萃分析研究。IBD、溃疡性结肠炎（UC）和克罗恩病（CD）与 患病率呈负相关（均<0.001）。荟萃分析结果显示，与对照组相比，IBD、CD 和 UC 感染者发生的可能性分别为 0.44、0.36 和 0.54（OR=0.44，95%CI=0.34-0.59；OR=0.36，95%CI=0.26-0.49；OR=0.54，95%CI=0.4-0.72）。此外，IBD 患者在根除后复发的可能性增加了 1.41 倍（OR=1.41，95%CI=1.25-1.58）。最后，感染与 IBD 药物和分类无关。
患病率与 IBD 呈负相关，对 IBD 具有保护作用。此外，根除会导致 IBD 复发。
