Tachi Tomoya, Teramachi Hitomi, Tanaka Kazuhide, Asano Shoko, Osawa Tomohiro, Kawashima Azusa, Yasuda Masahiro, Mizui Takashi, Nakada Takumi, Noguchi Yoshihiro, Tsuchiya Teruo, Goto Chitoshi
Laboratory of Clinical Pharmacy, Gifu Pharmaceutical University, Gifu, Japan; Department of Pharmacy, Gifu Municipal Hospital, Gifu, Japan.
Laboratory of Clinical Pharmacy, Gifu Pharmaceutical University, Gifu, Japan.
PLoS One. 2015 Apr 27;10(4):e0124169. doi: 10.1371/journal.pone.0124169. eCollection 2015.
The objective of our study was to clarify the impact of adverse events associated with the initial course of outpatient chemotherapy on the quality of life of breast cancer patients. We conducted a survey to assess the quality of life in 48 breast cancer patients before and after receiving their first course of outpatient chemotherapy at Gifu Municipal Hospital. Patients completed the European Quality of Life 5 Dimensions and Quality of Life Questionnaire for Cancer Patients Treated with Anticancer Drugs before and after 1 course of outpatient chemotherapy. European Quality of Life 5 Dimensions utility value and Quality of Life Questionnaire for Cancer Patients Treated with Anticancer Drugs total score decreased significantly after chemotherapy (p<0.001 and p = 0.018, respectively). The mean scores for the activity, physical condition, and psychological condition subscales of the Quality of Life Questionnaire for Cancer Patients Treated with Anticancer Drugs decreased significantly after chemotherapy (p = 0.003, p<0.001, and p = 0.032, respectively), whereas the social relationships score increased significantly (p<0.001). Furthermore, in the evaluation of quality of life according to individual adverse events, the decrease in quality of life after chemotherapy in terms of the European Quality of Life 5 Dimensions utility value and the Quality of Life Questionnaire for Cancer Patients Treated with Anticancer Drugs total score was greater in anorexic patients than in non-anorexic patients (p = 0.009 and p<0.001, respectively). This suggests that anorexia greatly reduces quality of life. Our findings reveal that anticancer drug-related adverse events, particularly anorexia, reduce overall quality of life following the first course of outpatient chemotherapy in current breast cancer patients. These findings are extremely useful and important in understanding the impact of anticancer drug-related adverse events on quality of life.
我们研究的目的是阐明门诊化疗初始疗程相关不良事件对乳腺癌患者生活质量的影响。我们进行了一项调查，以评估48例乳腺癌患者在岐阜市立医院接受首个门诊化疗疗程前后的生活质量。患者在门诊化疗1个疗程前后完成了欧洲五维健康量表和抗癌药物治疗癌症患者生活质量问卷。化疗后，欧洲五维健康量表效用值和抗癌药物治疗癌症患者生活质量问卷总分显著下降（分别为p<0.001和p = 0.018）。抗癌药物治疗癌症患者生活质量问卷中活动、身体状况和心理状况子量表的平均得分在化疗后显著下降（分别为p = 0.003、p<0.001和p = 0.032），而社会关系得分显著增加（p<0.001）。此外，在根据个体不良事件评估生活质量时，厌食患者化疗后欧洲五维健康量表效用值和抗癌药物治疗癌症患者生活质量问卷总分方面的生活质量下降幅度大于非厌食患者（分别为p = 0.009和p<0.001）。这表明厌食极大地降低了生活质量。我们的研究结果显示，抗癌药物相关不良事件，尤其是厌食，会降低当前乳腺癌患者首个门诊化疗疗程后的总体生活质量。这些发现对于理解抗癌药物相关不良事件对生活质量的影响极为有用且重要。
