白细胞介素 6-174(G/C)启动子多态性在早发型子痫前期发病机制中的作用。
Role of IL-6 -174(G/C) promoter polymorphism in the etiology of early-onset preeclampsia.
机构信息
Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet, Hyderabad, 500 016, India.
出版信息
Inflamm Res. 2015 Jun;64(6):433-9. doi: 10.1007/s00011-015-0823-z. Epub 2015 Apr 28.
OBJECTIVE
To investigate the relationship between IL-6 -174G/C promoter polymorphism and preeclampsia.
METHODS
A total of 140 preeclamptic women and 135 women with normal pregnancy were considered for the present study. A standard amplification refractory mutation system PCR was carried out for genotyping of IL-6 G-174C promoter polymorphism. Genotypic distribution was compared with values predicted by Hardy-Weinberg equilibrium using χ (2) test. Odds ratios and their respective 95 % confidence intervals were used to measure the strength of association.
RESULTS
The frequencies observed, CC, GC and GG, were 53.5, 26.6 and 20 % in patients and 26.6, 23.7 and 49.6 % in the controls. There is a significant difference in the distribution of genotypes and alleles of IL-6 G-174 C between the two groups.
CONCLUSION
The present study suggests that the IL-6 -174 promoter polymorphism is a major genetic regulator in the etiology of early-onset preeclampsia.
目的
探讨白细胞介素 6（IL-6）-174G/C 启动子多态性与子痫前期的关系。
方法
本研究共纳入 140 例子痫前期患者和 135 例正常妊娠妇女。采用标准扩增受阻突变系统 PCR 对 IL-6 G-174C 启动子多态性进行基因分型。采用 χ 2 检验比较基因型分布与 Hardy-Weinberg 平衡预测值。采用比值比（OR）及其 95%置信区间（CI）来衡量关联的强度。
结果
患者组中 CC、GC 和 GG 的频率分别为 53.5%、26.6%和 20%，对照组中分别为 26.6%、23.7%和 49.6%。两组间 IL-6 G-174C 基因型和等位基因的分布存在显著差异。
结论
本研究提示 IL-6-174 启动子多态性是早发型子痫前期发病的主要遗传调节因子。
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