Gariballa Salah, Alkaabi Juma, Yasin Javed, Al Essa Awad
Department of Internal Medicine, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates. E-mail.
Saudi Med J. 2017 Sep;38(9):960-964. doi: 10.15537/smj.2017.9.19629.
To establish whether body mass index (BMI) or waist circumference (WC) is a better predictor of cardio metabolic risk factors that are associated with increased visceral fat among obese women from the United Arab Emirates (UAE).
In this cross-sectional study, 333 obese subjects visiting community health centers in Al Ain city, UAE, were recruited between 2012 and 2015. After a written consent subjects had anthropometric, clinical and biochemical measurements. Fasting serum and plasma samples were collected for the measurement of markers of oxidative damage, antioxidants and inflammation. Outcome measures were compared between 4 equal BMI and WC quartiles.
We observed significantly higher blood pressure, c-reactive protein levels, IL6 levels, and protein carbonyls contents and lower β-carotene levels in the fourth quartile than in the first quartile for both BMI and WC (p less than 0.01). Glutathione peroxidase and adiponectin both decreased and TNF-α increased with increasing WC quartiles but not BMI quartiles; however, the results were statistically significant only for TNF-α (p=0.032). Conclusion: Both elevated BMI and elevated WC are associated with increased cardio metabolic risk factors in obese Emirati women; however, WC is a stronger predictor than is BMI.
确定体重指数（BMI）或腰围（WC）是否能更好地预测与阿联酋肥胖女性内脏脂肪增加相关的心血管代谢危险因素。
在这项横断面研究中，2012年至2015年间招募了333名前往阿联酋艾因市社区健康中心就诊的肥胖受试者。在获得书面同意后，对受试者进行了人体测量、临床和生化测量。采集空腹血清和血浆样本，用于测量氧化损伤、抗氧化剂和炎症标志物。在4个相等的BMI和WC四分位数之间比较结果指标。
我们观察到，BMI和WC的第四个四分位数中的血压、C反应蛋白水平、IL6水平和蛋白质羰基含量显著高于第一个四分位数，而β-胡萝卜素水平则较低（p<0.01）。随着WC四分位数的增加，谷胱甘肽过氧化物酶和脂联素均降低，TNF-α升高，但BMI四分位数无此变化；然而，结果仅对TNF-α具有统计学意义（p=0.032）。结论：BMI升高和WC升高均与肥胖阿联酋女性心血管代谢危险因素增加相关；然而，WC比BMI是更强的预测指标。
