†Institute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama 930-0194, Japan.
‡Department of Chemistry, University of Yangon, Yangon 11041, Myanmar.
J Nat Prod. 2015 May 22;78(5):1113-8. doi: 10.1021/acs.jnatprod.5b00108. Epub 2015 Apr 28.
Eight new diterpenoids, kaempulchraols A-H (1-8), along with five known analogues were isolated from the CHCl3-soluble extract of rhizomes of Kaempferia pulchra of Myanmar. The structures of these compounds were elucidated using extensive spectroscopic techniques including X-ray diffraction analysis. All the isolates were tested for their antiproliferative activity against a panel of five human cancer cell lines (A549, human lung cancer; HeLa, human cervix cancer; PANC-1 and PSN-1, human pancreatic cancer; MDA-MB-231, human breast cancer) and TIG-3, normal human primary fibroblast cells. Kaempulchraol F (6) exhibited weak activity against the human pancreatic PSN-1 cell line with an IC50 value of 12.3 μM.
从缅甸的蓬莪术根茎的 CHCl3 可溶提取物中分离得到了 8 个新的二萜类化合物，即坎普吕醇 A-H（1-8），以及 5 个已知类似物。这些化合物的结构通过包括 X 射线衍射分析在内的广泛光谱技术阐明。所有分离物均针对五种人类癌细胞系（A549，人肺癌；HeLa，人宫颈癌；PANC-1 和 PSN-1，人胰腺癌细胞；MDA-MB-231，人乳腺癌）和 TIG-3 正常人类原代成纤维细胞进行了抗增殖活性测试。坎普吕醇 F（6）对人胰腺 PSN-1 细胞系表现出较弱的活性，IC50 值为 12.3 μM。
