Twenty-five loci form a continuous linkage map of markers for human chromosome 7.

作者信息

Lathrop G M, O'Connell P, Leppert M, Nakamura Y, Farrall M, Tsui L C, Lalouel J M, White R

机构信息

Howard Hughes Medical Institute, University of Utah School of Medicine, Salt Lake City 84132.

出版信息

Genomics. 1989 Nov;5(4):866-73. doi: 10.1016/0888-7543(89)90128-6.

We have constructed a primary genetic linkage map from DNA markers that define 25 loci on chromosome 7. The markers form a continuous linkage group of 141 cM in males and 340 cM in females; female genetic distances were on average more than twofold higher than those in males throughout the chromosome. The average heterozygosity of the loci was 45%. A subset of the markers can be used for efficient application of this map to studies of human genetic disease.