28个基因座构成了人类1号染色体标记的连续连锁图谱。
Twenty-eight loci form a continuous linkage map of markers for human chromosome 1.
作者信息
O'Connell P, Lathrop G M, Nakamura Y, Leppert M L, Ardinger R H, Murray J L, Lalouel J M, White R
机构信息
Howard Hughes Medical Institute, University of Utah Medical School, Salt Lake City 84132.
出版信息
Genomics. 1989 Jan;4(1):12-20. doi: 10.1016/0888-7543(89)90308-x.
We have used a combination of 30 serological, protein electromorphic, and DNA markers defining 28 loci to construct a linkage map of chromosome 1. These markers form a continuous linkage group of 320 cM in males and 608 cM in females; female genetic distances were on average twofold higher than those of males across the map. Among the DNA markers are 10 highly polymorphic markers reflecting loci that contain a variable number of tandem repeats, well distributed over the length of the chromosome, that will be highly efficient anchor points for application of this map to studies of human genetic disease.
我们使用了30种血清学、蛋白质电形态和DNA标记的组合来定义28个基因座，构建了1号染色体的连锁图谱。这些标记在男性中形成了一个长度为320厘摩的连续连锁群，在女性中为608厘摩；在整个图谱上，女性的遗传距离平均是男性的两倍。在这些DNA标记中有10个高度多态性标记，反映了含有可变数量串联重复序列的基因座，它们在染色体长度上分布良好，将成为把该图谱应用于人类遗传疾病研究的高效锚定标记。
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