联合应用血管破坏剂和纳米药物根除外周和中枢区域的肿瘤。
Coadministration of Vascular Disrupting Agents and Nanomedicines to Eradicate Tumors from Peripheral and Central Regions.
机构信息
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China.
出版信息
Small. 2015 Aug;11(31):3755-61. doi: 10.1002/smll.201500324. Epub 2015 Apr 28.
A strategy for enhancing the treatment efficacy of nanomedicines within the central region of solid tumors is developed by combining nanomedicines and free small-molecule vascular disrupting agents (VDAs). The nanomedicines (cis-diamminedichloroplatinum-loaded nanoparticles) primarily target cells at the tumor periphery whereas the free small-molecule VDA (combretastatin A4 disodium phosphate) efficiently kills the cancer cells within the central regions of the tumor.
通过联合纳米药物和游离小分子血管破坏剂（VDA），开发了一种增强实体肿瘤中心区域内纳米药物治疗效果的策略。纳米药物（顺铂载药纳米颗粒）主要针对肿瘤边缘的细胞，而游离的小分子 VDA（康普瑞汀 A4 二钠盐）则有效地杀死肿瘤中心区域的癌细胞。
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