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抑郁症的进化理论

The Evolutionary Theory of Depression.

作者信息

Gałecki Piotr, Talarowska Monika

机构信息

Department of Adult Psychiatry, Medical University of Łódź, Łódź, Poland.

出版信息

Med Sci Monit. 2017 May 13;23:2267-2274. doi: 10.12659/msm.901240.

DOI:10.12659/msm.901240
PMID:28500855
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5439380/
Abstract

The evolutionary success of Homo sapiens is attributed to the following two factors: the upright body posture (which freed our hands and allowed unconstrained operation of various objects) and intensive development of the frontal lobes, mainly the Broca area of the brain. Underlining the uniqueness of the human brain, we often forget about the fact that the frontal lobes - the most developed part of the brain - are at the same time our greatest weakness, exposed to the action of damaging factors in our evolving environment. Is depression the cost of evolution?

摘要

智人的进化成功归因于以下两个因素

直立的身体姿势（解放了我们的双手，使我们能够无拘无束地操作各种物体）以及额叶，主要是大脑布洛卡区的高度发育。在强调人类大脑独特性的同时，我们常常忽略这样一个事实：额叶——大脑最发达的部分——同时也是我们最大的弱点，在我们不断演变的环境中容易受到损害因素的影响。抑郁症是进化的代价吗？

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e547/5439380/db9d0ef4b380/medscimonit-23-2267-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e547/5439380/e2cbf6069b43/medscimonit-23-2267-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e547/5439380/db9d0ef4b380/medscimonit-23-2267-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e547/5439380/e2cbf6069b43/medscimonit-23-2267-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e547/5439380/db9d0ef4b380/medscimonit-23-2267-g002.jpg

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BMC Public Health. 2016 Jul 30;16:675. doi: 10.1186/s12889-016-3352-y.
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Neuropsychological and neuroimaging evidence for the involvement of the frontal lobes in depression: 20 years on.额叶参与抑郁症的神经心理学及神经影像学证据：二十年回顾。
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Inflammation, infection and depression: an evolutionary perspective.炎症、感染与抑郁：进化视角
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Association of Polymorphic Variants in Argonaute Genes with Depression Risk in a Polish Population.波兰人群中 Argonaute 基因多态性与抑郁症风险的关联。
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