冰凉花苷L - P，从冰凉花根部提取的五种新强心苷类糖苷。

Amurensiosides L-P, five new cardenolide glycosides from the roots of Adonis amurensis.

作者信息

Kubo Satoshi, Kuroda Minpei, Yokosuka Akihito, Sakagami Hiroshi, Mimaki Yoshihiro

出版信息

Nat Prod Commun. 2015 Jan;10(1):27-32.

PMID:25920213

Abstract

Five new cardenolide glycosides, amurensiosides L-P (1-5), were isolated from the roots of Adonis amurensis. Their structures were determined based on extensive spectroscopic analysis, including two-dimensional (2D) NMR data, and on the results of hydrolytic cleavage. Compounds 1-5 were evaluated for their cytotoxic activities against HL-60 human promyelocytic leukemia and HSC-2 human oral squamous cell carcinoma cell lines.

摘要

从冰凉花的根部分离出了五种新的强心苷糖苷，即冰凉花苷L - P（1 - 5）。它们的结构是基于广泛的光谱分析确定的，包括二维（2D）核磁共振数据，以及水解裂解的结果。对化合物1 - 5针对HL - 60人早幼粒细胞白血病细胞和HSC - 2人口腔鳞状细胞癌细胞系的细胞毒性活性进行了评估。