Shang Xiaofei, Miao Xiaolou, Yang Feng, Wang Chunmei, Li Bing, Wang Weiwei, Pan Hu, Guo Xiao, Zhang Yu, Zhang Jiyu
Key Laboratory of New Animal Drug Project, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou, China.
Key Laboratory of Veterinary Pharmaceutical Development of Ministry of Agriculture, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou, China.
Front Pharmacol. 2019 Feb 4;10:25. doi: 10.3389/fphar.2019.00025. eCollection 2019.
The genus L. (Ranunculaceae), native to Europe and Asia, comprises 32 annual or perennial herbaceous species. Due to their cardiac-enhancing effects, spp. have long been used in European and Chinese folk medicine. These plants have been widely investigated since the late 19th century, when the cardiovascular activity of L. was noted in Europe. The present paper provides a review of the phytochemistry, biological activities and toxicology in order to highlight the future prospects of the genus. More than 120 chemical compounds have been isolated, with the most important components being cardiac glycosides as well as flavones, carotenoids, coumarins and other structural types. Plants of the genus, especially L. and Regel & Radde, their extracts and their active constituents possess broad pharmacological properties, including cardiovascular, antiangiogenic, antibacterial, antioxidant, anti-inflammatory and acaricidal activities, and exhibit both diuretic effects and effects on the central nervous system. However, most plants within the 32 species have not been comprehensively studied, and further clinical evaluation of their cardiovascular activity and toxicity should be conducted after addressing the problem of the rapidly decreasing resources. This review provides new insight into the genus and lays a solid foundation for further development of .
毛茛属（毛茛科）原产于欧洲和亚洲，包含32种一年生或多年生草本植物。由于其对心脏的增强作用，毛茛属植物长期以来被用于欧洲和中国的民间医学。自19世纪末欧洲注意到毛茛属植物的心血管活性以来，对这些植物进行了广泛研究。本文对其植物化学、生物活性和毒理学进行综述，以突出该属植物的未来前景。已分离出120多种化合物，其中最重要的成分是强心苷以及黄酮类、类胡萝卜素、香豆素和其他结构类型。该属植物，尤其是毛茛和兴安毛茛及其提取物和活性成分具有广泛的药理特性，包括心血管、抗血管生成、抗菌、抗氧化、抗炎和杀螨活性，并具有利尿作用和对中枢神经系统的作用。然而，32个物种中的大多数植物尚未得到全面研究，在解决资源迅速减少的问题后，应对其心血管活性和毒性进行进一步的临床评估。本综述为该属植物提供了新的见解，并为毛茛属植物的进一步开发奠定了坚实基础。
