Huynh Andrew, McGrath Christian, Johnson Douglas, Burrell Louise M
Department of General Medicine, Austin Health, Heidelberg, Victoria, Australia.
Department of Infectious Diseases, Austin Health, Heidelberg, Victoria, Australia.
BMJ Case Rep. 2015 Apr 28;2015:bcr2014208875. doi: 10.1136/bcr-2014-208875.
A 34-year-old man presented with a 6-day history of diarrhoea, abdominal cramps and fever. Blood cultures were initially reported as positive for Escherichia coli using matrix-assisted laser desorption/ionisation time of flight (MALDI-TOF) mass spectrometry. Contrast CT of the abdomen and pelvis revealed pancolitis and terminal ileal thickening. The patient was treated empirically with ampicillin, ciprofloxacin and metronidazole. Stool cultures were positive for Shigella sonnei. Subsequent testing on the initial blood culture correctly identified the organism as S. sonnei. On further questioning, the patient reported unprotected men who have sex with men (MSM) 3 months previously. His symptoms resolved during his 3-day admission, and he was discharged on 14 days of ciprofloxacin. He remains well. This case highlights that shigellosis is increasingly seen in MSM, with no history of travel, and may result in bacteraemia. This case also highlights the benefits (rapid identification of organisms) and limitations (inability to distinguish between E. coli and Shigella spp) of new technologies such as MALDI-TOF.
一名34岁男性,有6天腹泻、腹部绞痛和发热病史。最初使用基质辅助激光解吸/电离飞行时间(MALDI-TOF)质谱法报告血培养大肠埃希菌阳性。腹部和盆腔增强CT显示全结肠炎和末端回肠增厚。患者接受了氨苄西林、环丙沙星和甲硝唑的经验性治疗。粪便培养宋内志贺菌阳性。对最初血培养的后续检测正确鉴定该病原体为宋内志贺菌。进一步询问时,患者报告3个月前有与男性发生无保护性行为(男男性行为者,MSM)史。他在住院3天期间症状缓解,出院时接受了14天的环丙沙星治疗。他目前情况良好。该病例突出表明,在无旅行史的男男性行为者中志贺菌病越来越常见,且可能导致菌血症。该病例还突出了MALDI-TOF等新技术的优点(快速鉴定病原体)和局限性(无法区分大肠埃希菌和志贺菌属)。