金霉素生物合成利用一对保守的氧化酶进行B环收缩。
Kinamycin biosynthesis employs a conserved pair of oxidases for B-ring contraction.
作者信息
Wang Bin, Ren Jinwei, Li Liyuan, Guo Fang, Pan Guohui, Ai Guomin, Aigle Bertrand, Fan Keqiang, Yang Keqian
机构信息
State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, 100101 Beijing, China.
出版信息
Chem Commun (Camb). 2015 May 25;51(42):8845-8. doi: 10.1039/c5cc01986a.
The biosynthesis of diazobenzofluorene kinamycins requires a hitherto uncharacterized B-ring contraction. Via detailed genetic and enzymatic analyses we unambiguously characterized the conserved pairs of oxidases, AlpJ and AlpK homologs, as nature's machinery for benzofluorenone formation, which paves the way for the investigation of the following diazo assembly.
重氮苯并芴基那霉素的生物合成需要一种迄今尚未被表征的B环收缩。通过详细的遗传学和酶学分析，我们明确地将保守的氧化酶对AlpJ和AlpK同源物表征为自然界中形成苯并芴酮的机制，这为后续重氮组装的研究铺平了道路。
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