Department of Medicine and Surgery, University of Salerno, Salerno, Italy ; Division of Epidemiology and Public Health, City Hospital Campus, University of Nottingham, Nottingham, UK ; Campania Region Celiac Network, Campania, Italy.
Division of Epidemiology and Public Health, City Hospital Campus, University of Nottingham, Nottingham, UK.
United European Gastroenterol J. 2015 Apr;3(2):182-9. doi: 10.1177/2050640615571021.
There exists a wide variation in the reported incidence of coeliac disease in recent decades. We aimed to evaluate the incidence rate of coeliac diagnoses performed in an Italian region, Campania, between 2011 and 2013 and its variation therein.
All coeliac diagnoses made from 2011 to 2013 and registered within the Campania coeliac disease register (CeliacDB) were identified. Incidence rates were analysed by sex, age and province of residence, with a Poisson model fitted to determine incidence rate ratios.
We found 2049 coeliac disease diagnoses registered in the CeliacDB between 2011 and 2013; 1441 of these patients were female (70.4%) and 1059 were aged less than 19 years (51.7%). The overall incidence of coeliac disease in Campania was 11.8 per 100,000 person-years (95% CI 11.3-12.3) during the study period, with marked variation by age [27.4 per 100,000 person-years (95% CI 25.8-29.1) in children under 19 years of age and 7.3 per 100,000 (95% CI 6.8-7.8) in adults] and sex [16.1 per 100,000 person-years in females (95% CI 15.3-16.9) and 7.2 per 100,000 person-years in males (95% CI 6.6-7.8)]. Coeliac disease incidence was roughly similar in Naples, Salerno, Caserta and Avellino, but about half in Benevento. More than 80% of our study population was diagnosed by the combination of positive antitransglutaminase IgA and Marsh 3. More than half of the patients were symptomatic at the time of coeliac disease diagnosis (39.7% had a classical presentation and 21.1% a non-classical one according to the Oslo definition).
Coeliac disease incidence was roughly similar among Campania provinces, except in Benevento where it was about half, probably due to less awareness of coeliac disease in this area. The incidence of coeliac disease in Campania appears to be lower than that reported by most of the previous literature, suggesting the necessity of new coeliac awareness programmes.
近几十年来，乳糜泻的报告发病率存在广泛差异。我们旨在评估意大利坎帕尼亚地区 2011 年至 2013 年间进行的乳糜泻诊断的发病率及其变化。
确定了 2011 年至 2013 年间在坎帕尼亚乳糜泻登记处（CeliacDB）登记的所有乳糜泻诊断。通过性别、年龄和居住省份分析发病率，使用泊松模型确定发病率比。
我们发现 2011 年至 2013 年间 CeliacDB 中登记了 2049 例乳糜泻诊断；其中 1441 例患者为女性（70.4%），1059 例患者年龄小于 19 岁（51.7%）。在研究期间，坎帕尼亚的乳糜泻总发病率为每 100000 人年 11.8 例（95%CI 11.3-12.3），年龄差异显著[19 岁以下儿童每 100000 人年 27.4 例（95%CI 25.8-29.1），成人每 100000 人年 7.3 例（95%CI 6.8-7.8）]和性别[女性每 100000 人年 16.1 例（95%CI 15.3-16.9），男性每 100000 人年 7.2 例（95%CI 6.6-7.8）]。乳糜泻的发病率在那不勒斯、萨勒诺、卡塞塔和阿韦利诺大致相似，但在贝内文托约为一半。我们研究人群的 80%以上是通过阳性抗转谷氨酰胺酶 IgA 和 Marsh 3 联合诊断出来的。超过一半的患者在乳糜泻诊断时出现症状（根据奥斯陆定义，39.7%表现为典型，21.1%表现为非典型）。
除贝内文托外，坎帕尼亚各省份的乳糜泻发病率大致相似，在贝内文托约为一半，可能是由于该地区对乳糜泻的认识较低。坎帕尼亚乳糜泻的发病率似乎低于大多数先前文献报道的发病率，表明有必要开展新的乳糜泻宣传计划。
