Seo Kyung Hoon, Yu Seung-Young, Kwak Hyung Woo
Department of Ophthalmology, Kyung Hee University Hospital, Kyung Hee University, Seoul, Korea.
Retina. 2015 Sep;35(9):1828-35. doi: 10.1097/IAE.0000000000000563.
To evaluate the topographic changes in macular ganglion cell-inner plexiform layer (GCIPL) thickness after vitrectomy with indocyanine green-guided internal limiting membrane (ILM) peeling in eyes with idiopathic macular hole.
This is a retrospective analysis of 58 consecutive eyes with surgically closed macular hole after vitrectomy with indocyanine green-guided ILM peeling. Further, 31 eyes that had undergone vitrectomy without ILM peeling were used as the control group. The macular GCIPL thickness was measured with spectral domain optical coherence tomography before vitrectomy and at 1 month and 6 months after vitrectomy.
The preoperative mean GCIPL thickness was 78.79 μm and mean thickness at 1 month and 6 months after surgery significantly reduced progressively to 70.93 μm and 67.64 μm (P < 0.001 and P < 0.001, respectively). The postoperative mean GCIPL thickness was significantly lower than that of the group without ILM peeling at 1 month and 6 months postoperatively (P < 0.001, P < 0.001, respectively). The GCIPL thickness in the temporal area was significantly lower than in the nasal area at 1 month and 6 months postoperatively (P < 0.001, P < 0.001, respectively).
A reduction of the macular GCIPL thickness was observed after vitrectomy with indocyanine green-guided ILM peeling for idiopathic macular hole, especially in the temporal area.
评估在特发性黄斑裂孔眼行玻璃体切割联合吲哚菁绿引导内界膜（ILM）剥除术后黄斑神经节细胞-内丛状层（GCIPL）厚度的地形图变化。
这是一项对58只连续行玻璃体切割联合吲哚菁绿引导ILM剥除术后手术封闭黄斑裂孔眼的回顾性分析。另外，将31只未行ILM剥除的玻璃体切割术眼作为对照组。在玻璃体切割术前以及术后1个月和6个月，用频域光学相干断层扫描测量黄斑GCIPL厚度。
术前GCIPL平均厚度为78.79μm，术后1个月和6个月的平均厚度显著逐渐降低至70.93μm和67.64μm（分别为P < 0.001和P < 0.001）。术后1个月和6个月时，GCIPL平均厚度显著低于未行ILM剥除组（分别为P < 0.001，P < 0.001）。术后1个月和6个月时，颞侧区域的GCIPL厚度显著低于鼻侧区域（分别为P < 0.001，P < 0.001）。
在特发性黄斑裂孔眼行玻璃体切割联合吲哚菁绿引导ILM剥除术后观察到黄斑GCIPL厚度降低，尤其是在颞侧区域。
