Serano Peter, Angelone Leonardo M, Katnani Husam, Eskandar Emad, Bonmassar Giorgio
Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, U.S.A.
Department of Electrical and Computer Engineering, University of Maryland, College Park, MD, U.S.A.
Sci Rep. 2015 Apr 29;5:9805. doi: 10.1038/srep09805.
Clinical electrical stimulation systems--such as pacemakers and deep brain stimulators (DBS)--are an increasingly common therapeutic option to treat a large range of medical conditions. Despite their remarkable success, one of the significant limitations of these medical devices is the limited compatibility with magnetic resonance imaging (MRI), a standard diagnostic tool in medicine. During an MRI exam, the leads used with these devices, implanted in the body of the patient, act as an electric antenna potentially causing a large amount of energy to be absorbed in the tissue, which can lead to serious heat-related injury. This study presents a novel lead design that reduces the antenna effect and allows for decreased tissue heating during MRI. The optimal parameters of the wire design were determined by a combination of computational modeling and experimental measurements. The results of these simulations were used to build a prototype, which was tested in a gel phantom during an MRI scan. Measurement results showed a three-fold decrease in heating when compared to a commercially available DBS lead. Accordingly, the proposed design may allow a significantly increased number of patients with medical implants to have safe access to the diagnostic benefits of MRI.
临床电刺激系统,如起搏器和深部脑刺激器(DBS),正日益成为治疗多种医疗病症的常用治疗选择。尽管它们取得了显著成功,但这些医疗设备的一个重大局限性是与磁共振成像(MRI)(医学中的一种标准诊断工具)的兼容性有限。在MRI检查期间,与这些设备一起使用的植入患者体内的导线充当电天线,可能导致大量能量在组织中被吸收,这可能导致严重的热相关损伤。本研究提出了一种新颖的导线设计,可减少天线效应并在MRI期间减少组织发热。导线设计的最佳参数通过计算建模和实验测量相结合来确定。这些模拟结果被用于制造一个原型,该原型在MRI扫描期间在凝胶模型中进行了测试。测量结果表明,与市售的DBS导线相比,发热降低了三倍。因此,所提出的设计可能会使大量植入医疗设备的患者能够安全地获得MRI的诊断益处。