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Detection of the 43,000-molecular-weight glycoprotein in sera of patients with paracoccidioidomycosis.

作者信息

Mendes-Giannini M J, Bueno J P, Shikanai-Yasuda M A, Ferreira A W, Masuda A

机构信息

Departamento de Análises Clinicas, Faculdade de Ciências Farmacêuticas, UNESP, Araraquara, Brazil.

出版信息

J Clin Microbiol. 1989 Dec;27(12):2842-5. doi: 10.1128/jcm.27.12.2842-2845.1989.

DOI:10.1128/jcm.27.12.2842-2845.1989
PMID:2592544
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC267138/
Abstract

The 43,000-molecular-weight (43K) soluble glycoprotein was detected in sera of patients with paracoccidioidomycosis by the immunoblot technique by using as the probe rabbit monospecific antisera to this fraction. The 43K antigen was present before treatment in sera of patients with the acute (juvenile) form; it started to disappear from circulation after 10 months of chemotherapy, and it was undetectable after 2 years of treatment. In the chronic cases, the 43K antigen was detected in patients without treatment, and it was absent in the healed cases. The detection of the 43K protein specific to Paracoccidioides brasiliensis may be important for its diagnostic value as well as for modulation of the host immune response.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25ab/267138/0208f999efea/jcm00072-0236-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25ab/267138/544afa89ffb3/jcm00072-0235-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25ab/267138/704762bc2695/jcm00072-0235-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25ab/267138/b979263d0d28/jcm00072-0236-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25ab/267138/0208f999efea/jcm00072-0236-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25ab/267138/544afa89ffb3/jcm00072-0235-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25ab/267138/704762bc2695/jcm00072-0235-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25ab/267138/b979263d0d28/jcm00072-0236-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25ab/267138/0208f999efea/jcm00072-0236-b.jpg

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