Then Francisca S, Luck Tobias, Luppa Melanie, König Hans-Helmut, Angermeyer Matthias C, Riedel-Heller Steffi G
From the Institute of Social Medicine, Occupational Health and Public Health (F.S.T., T.L., M.L., S.G.R.-H.), and LIFE-Leipzig Research Center for Civilization Diseases (F.S.T., T.L.), University of Leipzig; Department of Health Economics and Health Services Research (H.-H.K.), University Medical Center Hamburg-Eppendorf, Germany; Center for Public Mental Health (M.C.A.), Gösing am Wagram, Austria; and Department of Public Health and Clinical and Molecular Medicine (M.C.A.), University of Cagliari, Italy.
Neurology. 2015 May 26;84(21):2169-76. doi: 10.1212/WNL.0000000000001605. Epub 2015 Apr 29.
The aim of the present study was to investigate how different mentally demanding work conditions during the professional life-i.e., enriched environments at work-might influence the rate of cognitive decline in old age.
Individuals (n = 1,054) of the Leipzig Longitudinal Study of the Aged, a representative population-based cohort study of individuals aged 75 years and older, underwent cognitive testing via the Mini-Mental State Examination (MMSE) in up to 6 measurement waves. Type and level of mentally demanding work conditions in the participants' former professional life were classified based on the O*NET job descriptor database.
In multivariate mixed-model analyses (controlling for sociodemographic and health-related factors), a high level of mentally demanding work tasks stimulating verbal intelligence was significantly associated with a better cognitive functioning at baseline (on average 5 MMSE points higher) as well as a lower rate of cognitive decline (on average 2 MMSE points less) over the 8-year follow-up period compared with a low level. The rate of cognitive decline in old age was also significantly lower (on average 3 MMSE points less) in individuals who had a high level of mentally demanding work tasks stimulating executive functions than those who had a low level.
The results suggest that a professional life enriched with work tasks stimulating verbal intelligence and executive functions may help to sustain a good cognitive functioning in old age (75+ years). The findings thus emphasize that today's challenging work conditions may also promote positive health effects.
本研究旨在调查职业生涯中不同的高脑力工作条件,即工作中的丰富环境,如何影响老年认知衰退的速率。
莱比锡老年纵向研究中的个体(n = 1054),这是一项基于人群的具有代表性的队列研究,研究对象为75岁及以上的个体,在多达6次测量波次中通过简易精神状态检查表(MMSE)进行认知测试。根据职业信息网络(O*NET)工作描述数据库对参与者过去职业生涯中高脑力工作条件的类型和水平进行分类。
在多变量混合模型分析(控制社会人口统计学和健康相关因素)中,与低水平相比,高水平的刺激语言智力的高脑力工作任务与基线时更好的认知功能(平均高出5个MMSE分数)以及8年随访期内较低的认知衰退速率(平均少2个MMSE分数)显著相关。与低水平的个体相比,高水平的刺激执行功能的高脑力工作任务的个体老年认知衰退速率也显著更低(平均少3个MMSE分数)。
结果表明,充满刺激语言智力和执行功能的工作任务的职业生涯可能有助于在老年(75岁及以上)维持良好的认知功能。这些发现因此强调,如今具有挑战性的工作条件也可能促进积极的健康影响。