Curzi-Dascalova L, Christova E, Peirano P, Singh B B, Gaultier C, Vicente G
INSERM, Laboratoire de Physiologie, Hôpital Antoine Béclère, Clamart, France.
J Dev Physiol. 1989 Jun;11(6):323-30.
To investigate the relationship between central respiratory pauses and heart rate, we performed polygraphic recordings in 23 normal newborns (35 to 41 weeks conceptional age). We monitored the electroencephalogram, rapid eye movements, movements of the upper and lower limbs, chin and diaphragmatic electromyogram, electrocardiogram, thoracic and abdominal respiratory movements, air flow and transcutaneous PO2. Heart rate changes were analysed by computer measurement of R-R intervals and by cardiotachography. Respiratory pauses occurring after body movements and those not preceded by movements were studied separately. We analysed 1128 respiratory pauses greater than 3 s duration. No respiratory pause lasted more than 12 s. Independently of age, sleep state and respiratory pause duration, heart rate was significantly lower at the onset of respiratory pause, compared to control periods (selected away from the pause: 10 s before its onset and 20 s after its end). Heart rate slowed still further through the respiratory pause and reverted toward the baseline level after its end. When no movements preceded the respiratory pause, heart rate just before the pause was lower compared to control periods. These findings suggest the existence of simultaneous central commands responsible for both respiratory pause and heart rate deceleration.
为了研究中枢性呼吸暂停与心率之间的关系，我们对23名正常新生儿（孕龄35至41周）进行了多导记录。我们监测了脑电图、快速眼动、上肢和下肢运动、颏部和膈肌肌电图、心电图、胸腹部呼吸运动、气流及经皮血氧分压。通过计算机测量R-R间期和心率计分析心率变化。分别研究了身体运动后出现的呼吸暂停和无运动前驱的呼吸暂停。我们分析了1128次持续时间超过3秒的呼吸暂停。没有一次呼吸暂停持续超过12秒。与对照期（选在呼吸暂停之前10秒和结束后20秒）相比，无论年龄、睡眠状态和呼吸暂停持续时间如何，呼吸暂停开始时心率均显著降低。在呼吸暂停期间心率进一步减慢，并在结束后恢复至基线水平。当呼吸暂停前无运动时，呼吸暂停前的心率与对照期相比更低。这些发现提示存在同时负责呼吸暂停和心率减慢的中枢指令。
