Nicholl J P, O'Cathain A
Department of Community Medicine, University of Sheffield Medical School.
J Epidemiol Community Health. 1989 Jun;43(2):133-9. doi: 10.1136/jech.43.2.133.
An analysis of data from the United Kingdom multicentre study of postneonatal mortality has been made to assess whether there are causally distinct groups of babies dying from the Sudden Infant Death Syndrome (SIDS), and to develop explicit risk factor profiles for the subgroups. The 303 SIDS babies in the multicentre study were divided into four subgroups by age at death: weeks 1-7, 8-15, 16-23, and 24 or more weeks. Contrasts between these subgroups with respect to 28 epidemiological characteristics and to pathology findings were investigated. Significant contrasts in the number of previous pregnancies, duration of the 2nd stage of labour, gestational length, family finances and repair of housing were found. Overall, very strong evidence of epidemiological differences was found (chi 2(9) = 29.3, p less than 0.001), and of contrasts in the nature and degree of any acquired terminal disease. It is concluded that there are different causes of SIDS with different distributions according to age at death.
对英国多中心新生儿后期死亡率研究的数据进行了分析，以评估是否存在因婴儿猝死综合征（SIDS）死亡的不同因果组，并为各亚组制定明确的风险因素概况。多中心研究中的303名SIDS婴儿按死亡年龄分为四个亚组：1 - 7周、8 - 15周、16 - 23周和24周及以上。研究了这些亚组在28项流行病学特征和病理结果方面的差异。发现既往妊娠次数、第二产程持续时间、孕周、家庭经济状况和房屋修缮情况存在显著差异。总体而言，发现了非常有力的流行病学差异证据（χ²(9) = 29.3，p < 0.001），以及任何获得性终末期疾病的性质和程度方面的差异。得出的结论是，SIDS存在不同病因，且根据死亡年龄分布各异。
