Tischer Christina, Zock Jan-Paul, Valkonen Maria, Doekes Gert, Guerra Stefano, Heederik Dick, Jarvis Deborah, Norbäck Dan, Olivieri Mario, Sunyer Jordi, Svanes Cecilie, Täubel Martin, Thiering Elisabeth, Verlato Giuseppe, Hyvärinen Anne, Heinrich Joachim
Institute of Epidemiology I, Helmholtz Zentrum München, Ingolstädter Landstrasse 1,German Research Centre for Environmental Health, D-85764, Neuherberg, Germany.
Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.
BMC Pulm Med. 2015 May 2;15:48. doi: 10.1186/s12890-015-0042-y.
Dampness and mould exposure have been repeatedly associated with respiratory health. However, less is known about the specific agents provoking or arresting health effects in adult populations. We aimed to assess predictors of microbial agents in mattress dust throughout Europe and to investigate associations between microbial exposures, home characteristics and respiratory health.
Seven different fungal and bacterial parameters were assessed in mattress dust from 956 adult ECRHS II participants in addition to interview based home characteristics. Associations between microbial parameters and the asthma score and lung function were examined using mixed negative binomial regression and linear mixed models, respectively.
Indoor dampness and pet keeping were significant predictors for higher microbial agent concentrations in mattress dust. Current mould and condensation in the bedroom were significantly associated with lung function decline and current mould at home was positively associated with the asthma score. Higher concentrations of muramic acid were associated with higher mean ratios of the asthma score (aMR 1.37, 95%CI 1.17-1.61). There was no evidence for any association between fungal and bacterial components and lung function.
Indoor dampness was associated with microbial levels in mattress dust which in turn was positively associated with asthma symptoms.
接触潮湿和霉菌反复与呼吸道健康相关。然而，对于引发或阻止成年人群健康影响的具体因素知之甚少。我们旨在评估欧洲各地床垫灰尘中微生物因子的预测因素，并调查微生物暴露、家庭特征与呼吸道健康之间的关联。
除了基于访谈的家庭特征外，还对956名欧洲社区呼吸健康调查（ECRHS）II期成年参与者的床垫灰尘中的七种不同真菌和细菌参数进行了评估。分别使用混合负二项回归和线性混合模型检查微生物参数与哮喘评分和肺功能之间的关联。
室内潮湿和饲养宠物是床垫灰尘中微生物因子浓度较高的重要预测因素。卧室当前的霉菌和冷凝现象与肺功能下降显著相关，家中当前的霉菌与哮喘评分呈正相关。较高浓度的胞壁酸与哮喘评分的较高平均比值相关（调整后平均比值1.37，95%置信区间1.17-1.61）。没有证据表明真菌和细菌成分与肺功能之间存在任何关联。
室内潮湿与床垫灰尘中的微生物水平相关，而这又与哮喘症状呈正相关。
