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GOS 通过脂代谢和肠道微生物改善高脂肪高糖饮食诱导的非酒精性脂肪肝。

GOS Ameliorates Nonalcoholic Fatty Liver Disease Induced by High Fat and High Sugar Diet through Lipid Metabolism and Intestinal Microbes.

机构信息

Guangdong Engineering Research Center of Natural Products and New Drugs, Guangdong Provincial University Engineering Technology Research Center of Natural Products and Drugs, Guangdong Pharmaceutical University, Guangzhou 510006, China.

Guangdong Metabolic Disease Research Center of Integrated Chinese and Western Medicine, Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China, Guangdong TCM Key Laboratory for Metabolic Diseases, Guangdong Pharmaceutical University, Guangzhou 510006, China.

出版信息

Nutrients. 2022 Jul 1;14(13):2749. doi: 10.3390/nu14132749.

DOI:10.3390/nu14132749
PMID:35807929
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9268751/
Abstract

The treatment of nonalcoholic fatty liver disease (NAFLD) remains very challenging. This study investigated the therapeutic effect of galactose oligosaccharide (GOS), an important prebiotic, on NAFLD through in vivo and in vitro experiments and preliminarily explored the mechanism by which GOS improves liver lipid metabolism and inflammation through liver and intestinal microbiological analysis. The results of mouse liver lipidomics showed that GOS could promote body thermogenesis in mice with high-fat and high-sugar diet (HFHSD)-induced NAFLD, regulate lipolysis in liver fat cells, and accelerate glycine and cholesterol metabolism. GOS dose-dependently reduced the contents of total cholesterol (TC) and triglyceride (TG) in cells and reduced the accumulation of lipid droplets in cells. GOS also reduced the Firmicutes/Bacteroidetes ratio and altered the composition of the intestinal microbiota in mice fed a HFHSD. GOS can improve liver lipid metabolism and intestinal structure of NAFLD. These results provide a theoretical and experimental basis supporting the use of GOS as a health food with anti-NAFLD functions.

摘要

非酒精性脂肪性肝病（NAFLD）的治疗仍然极具挑战性。本研究通过体内和体外实验研究了半乳糖寡糖（GOS）作为一种重要的益生元对 NAFLD 的治疗作用，并通过肝和肠道微生物分析初步探讨了 GOS 改善肝脂质代谢和炎症的机制。小鼠肝脂质组学结果表明，GOS 可促进高脂肪高糖饮食（HFHSD）诱导的 NAFLD 小鼠的体热生成，调节肝脂肪细胞的脂肪分解，并加速甘氨酸和胆固醇代谢。GOS 呈剂量依赖性降低细胞内总胆固醇（TC）和甘油三酯（TG）的含量，减少细胞内脂滴的堆积。GOS 还降低了 HFHSD 喂养小鼠的厚壁菌门/拟杆菌门比值，并改变了肠道微生物群落的组成。GOS 可改善 NAFLD 患者的肝脂质代谢和肠道结构。这些结果为 GOS 作为具有抗 NAFLD 功能的保健食品提供了理论和实验依据。

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