Zhang Jiaosheng, Zhao Ruizhen, Dong Yimei, Zheng Yuejie
Department of Internal Medicine, Shenzhen Children's Hospital Shenzhen 518038, P. R. China.
Department of Clinical Laboratory, Shenzhen Children's Hospital Shenzhen 518038, P. R. China.
Int J Clin Exp Med. 2015 Feb 15;8(2):2939-43. eCollection 2015.
In this study, we aim to investigate the distribution and antibiotic susceptibility of Group B Streptococcus (GBS) in infants younger than 90 days in Shenzhen, China.
A retrospective study was conducted to evaluate GBS infection over an 4-year period. Starting from January 2010, we evaluated the laboratory data, clinical manifestations, treatment and outcomes of patients admitted to our hospital with invasive GBS infection. Furthermore, we analyzed distribution of isolates from infants < 90 days with GBS or non-GBS invasive infection.
The registered cases of invasive GBS infection (n = 40, male: 23, female: 17) were classified as sepsis (n = 24), meningitis (n = 2), or both (n = 14). Patients with sepsis recovered completely. Among patients with meningitis, 1 (6.3%) died from ventricular hemorrhage, and 4 (25%) showed sequelae during the follow up of 3 months. Among the 377 isolates (45 from the 40 infants with invasive GBS infection, 332 from infants with non-GBS invasive infections), the detection rate of GBS was 11.9% (45/377), accounted for 11.2% of sepsis and 18.4% of meningitis cases. All 45 isolates were susceptible to penicillin, vancomycin, linezolid, tigecycline, and quinolones. Resistance to erythromycin, clindamycin, and tetracycline was found in 19 (42%), 29 (64%), and 42 (93%) isolates, respectively.
GBS is an important pathogen in infants < 90 days in Shenzhen, China, which results in high mortality and neurological sequelae. GBS strains show strong resistance to clindamycin and erythromycin.
本研究旨在调查中国深圳90日龄以下婴儿中B族链球菌（GBS）的分布及抗生素敏感性。
进行一项回顾性研究，评估4年期间的GBS感染情况。从2010年1月开始，我们评估了我院收治的侵袭性GBS感染患者的实验室数据、临床表现、治疗及转归。此外，我们分析了90日龄以下GBS或非GBS侵袭性感染婴儿分离株的分布情况。
登记的侵袭性GBS感染病例（n = 40，男：23例，女：17例）分为败血症（n = 24）、脑膜炎（n = 2）或两者皆有（n = 14）。败血症患者全部完全康复。在脑膜炎患者中，1例（6.3%）死于脑室出血，4例（25%）在3个月的随访期间出现后遗症。在377株分离株中（45株来自40例侵袭性GBS感染婴儿，332株来自非GBS侵袭性感染婴儿），GBS的检出率为11.9%（45/377），占败血症病例的11.2%，脑膜炎病例的18.4%。所有45株分离株对青霉素、万古霉素、利奈唑胺、替加环素和喹诺酮类均敏感。分别有19株（42%）、29株（64%）和42株（93%）分离株对红霉素、克林霉素和四环素耐药。
GBS是中国深圳90日龄以下婴儿的重要病原体，可导致高死亡率和神经后遗症。GBS菌株对克林霉素和红霉素耐药性较强。
