Bolton Eleanor M, Bradley John Andrew
Department of Surgery, University of Cambridge, Box 202, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.
Regen Med. 2015;10(3):287-304. doi: 10.2217/rme.15.11.
One of the major goals of regenerative medicine is repair or replacement of diseased and damaged tissues by transfer of differentiated stem cells or stem cell-derived tissues. The possibility that these tissues will be destroyed by immunological rejection remains a challenge that can only be overcome through a better understanding of the nature and expression of potentially immunogenic molecules associated with cell replacement therapy and the mechanisms and pathways resulting in their immunologic rejection. This review draws on clinical experience of organ and tissue transplantation, and on transplantation immunology research to consider practical approaches for avoiding and overcoming the possibility of rejection of stem cell-derived tissues.
再生医学的主要目标之一是通过转移分化的干细胞或干细胞衍生组织来修复或替换患病和受损组织。这些组织被免疫排斥破坏的可能性仍然是一个挑战，只有通过更好地理解与细胞替代疗法相关的潜在免疫原性分子的性质和表达，以及导致其免疫排斥的机制和途径才能克服。本综述借鉴了器官和组织移植的临床经验以及移植免疫学研究，来探讨避免和克服干细胞衍生组织被排斥可能性的实用方法。
