Di Muzio Laura, Paolicelli Patrizia, Brandelli Chiara, Cesa Stefania, Trilli Jordan, Petralito Stefania, Casadei Maria Antonietta
Department of Drug Chemistry and Technologies, Sapienza University of Rome, 00185 Rome, Italy.
Gels. 2021 Sep 24;7(4):150. doi: 10.3390/gels7040150.
Recently, we reported the synthesis and characterization of a new dextran derivative obtained by grafting polyethylene glycol methacrylate to a polysaccharide backbone through a carbonate bond. This moiety was introduced because it allows for the fabrication, through a photo-induced crosslinking reaction, of biodegradable hydrogels particularly suitable for the release of high molecular weight molecules. Here, we investigate the influence of the oxyethylene chain length and the molecular weight of the starting dextran on the main properties of the polymeric solutions as well as those of the corresponding hydrogels. All synthesized polymeric derivatives were characterized by FTIR, NMR, and rheological analyses. The photo-crosslinking reaction of the polymers allowed us to obtain biodegradable networks tested for their mechanical properties, swelling, and degradation behavior. The results showed that both the oxyethylene chain length as well as the molecular weight of the starting dextran influenced swelling and degradation of the hydrogel network. As a consequence, the different behaviors in terms of swelling and degradability were able to affect the release of a large model molecule over time, making these matrices suitable candidates for the delivery of high molecular weight drug substances.
最近，我们报道了一种新的葡聚糖衍生物的合成与表征，该衍生物是通过碳酸酯键将聚甲基丙烯酸乙二醇酯接枝到多糖主链上得到的。引入这个部分是因为它能够通过光诱导交联反应制备出特别适合释放高分子量分子的可生物降解水凝胶。在此，我们研究了氧化乙烯链长度和起始葡聚糖的分子量对聚合物溶液以及相应水凝胶主要性质的影响。所有合成的聚合物衍生物都通过傅里叶变换红外光谱（FTIR）、核磁共振（NMR）和流变学分析进行了表征。聚合物的光交联反应使我们能够获得可生物降解的网络，并对其机械性能、溶胀和降解行为进行测试。结果表明，氧化乙烯链长度以及起始葡聚糖的分子量都影响水凝胶网络的溶胀和降解。因此，在溶胀和可降解性方面的不同行为能够随时间影响大分子模型分子的释放，使这些基质成为递送高分子量药物物质的合适候选者。
