Bienkowski Przemyslaw, Samochowiec Jerzy, Pelka-Wysiecka Justyna, Grzywacz Anna, Skibinska Maria, Jasiewicz Andrzej, Tybura Piotr, Wroński Michał, Jarema Marek, Samochowiec Agnieszka
Department of Pharmacology, Institute of Psychiatry and Neurology, Warszawa, Poland.
Department of Psychiatry, Pomeranian Medical University, Szczecin, Poland.
Pharmacol Rep. 2015 Jun;67(3):442-5. doi: 10.1016/j.pharep.2014.11.007. Epub 2014 Nov 27.
The deficit subtype of schizophrenia is hypothesized to constitute a pathophysiologically distinct subgroup of schizophrenia patients suffering from enduring, idiopathic negative symptoms and various neuropsychological deficits. Matrix metalloproteinases (MMPs) are extracellularly acting endopeptidases the substrates of which are matrix and adhesion molecules. Recently, MMP9 has been shown to be involved in various forms of synaptic plasticity, learning and memory consolidation. The primary aim of the present study was to evaluate associations between the functional MMP-9 -1562C/T gene polymorphism and the deficit and non-deficit subtypes of schizophrenia.
The study was conducted between 2009 and 2012. Deficit schizophrenia was diagnosed using the SDS. The sample consisted of 468 patients, Caucasians, of Polish descent with ICD 10 diagnosis of schizophrenia: 189 [51% males] were included in a non-deficit subgroup, 279 patients [53% males] were included in a deficit subgroup. The control group consisted of 532 subjects, Caucasians, of Polish descent [51% males]. MMP-9 -1562C/T gene polymorphism was genotyped using the fluorescence resonance energy transfer (FRET) method and the Light Cycler System 2.0.
The frequencies of genotypes and alleles did not differ between the schizophrenia patients and control group. The deficit and non-deficit patients did not differ in terms of the genotype and allele frequencies. No differences were found in genotype and allele frequencies between the deficit patients and the controls and between the non-deficit patients and the controls.
We found no evidence for the association between the functional MMP-9 -1562C/T gene polymorphism and deficit/non-deficit subtypes of schizophrenia.
精神分裂症的缺陷亚型被认为是精神分裂症患者中一个病理生理上不同的亚组，这些患者存在持久的、特发性的阴性症状和各种神经心理学缺陷。基质金属蛋白酶（MMPs）是细胞外作用的内肽酶，其底物是基质和粘附分子。最近，MMP9已被证明参与各种形式的突触可塑性、学习和记忆巩固。本研究的主要目的是评估功能性MMP-9 -1562C/T基因多态性与精神分裂症的缺陷型和非缺陷型亚型之间的关联。
该研究于2009年至2012年进行。使用SDS诊断缺陷型精神分裂症。样本包括468名患有ICD 10精神分裂症诊断的波兰裔白种人患者：189名[51%为男性]被纳入非缺陷亚组，279名患者[53%为男性]被纳入缺陷亚组。对照组由532名波兰裔白种人受试者[51%为男性]组成。使用荧光共振能量转移（FRET）方法和Light Cycler System 2.0对MMP-9 -1562C/T基因多态性进行基因分型。
精神分裂症患者和对照组之间的基因型和等位基因频率没有差异。缺陷型和非缺陷型患者在基因型和等位基因频率方面没有差异。在缺陷型患者与对照组之间以及非缺陷型患者与对照组之间，基因型和等位基因频率均未发现差异。
我们没有发现功能性MMP-9 -1562C/T基因多态性与精神分裂症的缺陷型/非缺陷型亚型之间存在关联的证据。
