肉芽肿性多血管炎的心脏受累情况
Cardiac Involvement in Granulomatosis with Polyangiitis.
作者信息
McGeoch Lucy, Carette Simon, Cuthbertson David, Hoffman Gary S, Khalidi Nader, Koening Curry L, Langford Carol A, McAlear Carol A, Moreland Larry, Monach Paul A, Seo Philip, Specks Ulrich, Ytterberg Steven R, Merkel Peter A, Pagnoux Christian
机构信息
From the Division of Rheumatology, Mount Sinai Hospital, Toronto, Ontario, Canada; Health Informatics Institute, University of South Florida, Tampa, Florida; Center for Vasculitis Care and Research, Cleveland Clinic, Cleveland, Ohio, USA; Division of Rheumatology, McMaster University, Hamilton, Ontario, Canada; Division of Rheumatology, University of Utah, Salt Lake City, Utah; Division of Rheumatology, University of Pennsylvania, Philadelphia; Division of Rheumatology, University of Pittsburgh, Pennsylvania; The Vasculitis Center, Section of Rheumatology, and the Clinical Epidemiology Unit, Boston University School of Medicine, Boston, Massachusetts; Division of Rheumatology, Johns Hopkins University, Baltimore, Maryland; Division of Pulmonary and Critical Care Medicine, and the Division of Rheumatology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.L. McGeoch, MD; S. Carette, MD, Division of Rheumatology, Mount Sinai Hospital; D. Cuthbertson, MS, Health Informatics Institute, University of South Florida; G.S. Hoffman, MD, Center for Vasculitis Care and Research, Cleveland Clinic; N. Khalidi, MD, Division of Rheumatology, McMaster University; C.L. Koening, MD, Division of Rheumatology, University of Utah; C.A. Langford, MD, Center for Vasculitis Care and Research, Cleveland Clinic; C.A. McAlear, MA, Division of Rheumatology, University of Pennsylvania; L. Moreland, MD, Division of Rheumatology, University of Pittsburgh; P.A. Monach, MD, PhD, The Vasculitis Center, Section of Rheumatology, and the Clinical Epidemiology Unit, Boston University School of Medicine; P. Seo, MD, Division of Rheumatology, Johns Hopkins University; U. Specks, MD, Division of Pulmonary and Critical Care Medicine; S.R. Ytterberg, MD, Division of Rheumatology, Mayo Clinic College of Medicine; P.A. Merkel, MD, MPH, Division of Rheumatology, University of Pennsylvania; C. Pagnoux, MD, MSc, MPH, Division of Rheumatology, Mount Sinai Hospital.
出版信息
J Rheumatol. 2015 Jul;42(7):1209-12. doi: 10.3899/jrheum.141513. Epub 2015 May 1.
OBJECTIVE
To determine frequency and outcomes of granulomatosis with polyangiitis (GPA)-related cardiac disease in a North American GPA cohort.
METHODS
Analysis was done of all patients in the Vasculitis Clinical Research Consortium Longitudinal Study of GPA. Demographic and clinical characteristics of patients with and without GPA-related cardiac involvement were compared.
RESULTS
Of 517 patients with GPA, 3.3% had cardiac involvement. No differences were observed between patients with or without cardiac involvement in terms of demographics, antineutrophil cytoplasmic antibody positivity, or relapse rate.
CONCLUSION
Cardiac involvement in GPA is rare and heterogeneous. In this cohort, cardiac involvement was not associated with a higher rate of relapse or premature death.
目的
确定北美肉芽肿性多血管炎（GPA）队列中与GPA相关的心脏疾病的发生率及转归。
方法
对血管炎临床研究联盟GPA纵向研究中的所有患者进行分析。比较有和无GPA相关心脏受累患者的人口统计学和临床特征。
结果
517例GPA患者中，3.3%有心脏受累。有或无心脏受累的患者在人口统计学、抗中性粒细胞胞浆抗体阳性率或复发率方面均未观察到差异。
结论
GPA中的心脏受累罕见且具有异质性。在该队列中，心脏受累与较高的复发率或过早死亡无关。
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