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用于组织修复和再生的药物递送技术与干细胞。

Drug delivery technologies and stem cells for tissue repair and regeneration.

作者信息

Orive Gorka, Cobos Raquel, Gorriti Janire, Pedraz Jose L, Meregalli Mirella, Torrente Yvan

机构信息

Laboratory of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of the Basque Country, Vitoria, Spain.

出版信息

Curr Pharm Biotechnol. 2015;16(7):646-54. doi: 10.2174/138920101607150427112457.

DOI:10.2174/138920101607150427112457
PMID:25934974
Abstract

In the last few years several technologies are being developed for eventually repairing or replacing damaged or injured tissues and even organs. Some of these emerging technologies include the design and development of new biomaterials, the optimization of nano- and micro-technologies for drug and cell delivery, the use of autologous proteins or the application of stem cells as therapeutics. Thus, several types of stem cells, e.g. ESCs, iPSCs, MSCs, CD133+ stem cells are being evaluated for tissue regeneration purposes. The present review describes some of these emerging technologies and discusses their potential benefits and challenges.

摘要

在过去几年中,人们正在开发多种技术,最终用于修复或替换受损或受伤的组织甚至器官。其中一些新兴技术包括新型生物材料的设计与开发、用于药物和细胞递送的纳米和微技术的优化、自体蛋白质的使用或干细胞作为治疗手段的应用。因此,几种类型的干细胞,如胚胎干细胞、诱导多能干细胞、间充质干细胞、CD133+干细胞,正在被评估用于组织再生目的。本综述描述了其中一些新兴技术,并讨论了它们潜在的益处和挑战。

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