基于单过敏或多过敏的变应性鼻炎表型。
Allergic rhinitis phenotypes based on mono-allergy or poly-allergy.
机构信息
Section of Otolaryngology, Department of Neuroscience and Sensory Organs, University of Bari, Bari, Italy.
出版信息
Inflamm Res. 2015 Jun;64(6):373-5. doi: 10.1007/s00011-015-0826-9. Epub 2015 May 3.
BACKGROUND
Allergic rhinitis (AR) is characterized by typical symptoms that are dependent on inflammation. Poly-allergy is a frequent phenomenon. Phenotyping AR represents an up-to-date issue.
OBJECTIVE
The aim of this study was to evaluate whether the number of allergies is able to define different phenotypes in patients with AR.
METHODS
83 patients (43 males, mean age 34.7 years) suffering from AR were evaluated. Sensitization, VAS for nasal symptoms perception, and nasal cytology were evaluated.
RESULTS
Poly-allergic patients perceived more severe nasal obstruction than mono-allergic ones (p = 0.0006) as well as they had more frequent sneezing (p < 0.0001). Moreover, poly-allergic patients had a more intense inflammatory infiltrate, concerning both eosinophils (p = 0.0005) and mast cells (p = 0.0001), than mono-allergic patients.
CONCLUSIONS
The present study demonstrates that the presence of poly-allergy could define a distinct AR phenotype in comparison with mono-allergy. It could be clinically relevant as poly-allergic patients have more intense inflammation and more severe symptoms than mono-allergic ones.
背景
过敏性鼻炎（AR）的特征是依赖于炎症的典型症状。多过敏是一种常见现象。AR 的表型分析是一个最新的问题。
目的
本研究旨在评估过敏的数量是否能够定义 AR 患者的不同表型。
方法
评估了 83 名（43 名男性，平均年龄 34.7 岁）患有 AR 的患者。评估了过敏情况、鼻症状感知的视觉模拟量表（VAS）和鼻细胞学。
结果
多过敏患者比单过敏患者感知到更严重的鼻塞（p = 0.0006），并且更频繁地打喷嚏（p < 0.0001）。此外，多过敏患者的炎症浸润比单过敏患者更强烈，涉及嗜酸性粒细胞（p = 0.0005）和肥大细胞（p = 0.0001）。
结论
本研究表明，与单过敏相比，多过敏的存在可以定义为一种不同的 AR 表型。它在临床上可能具有相关性，因为多过敏患者的炎症和症状比单过敏患者更严重。
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