Song Yo-Han, An Ji-Hae, Seo Young-Woo, Moon Won-Jin, Park Yeong-Joon, Song Ho-Jun
J Nanosci Nanotechnol. 2014 Aug;14(8):5682-7. doi: 10.1166/jnn.2014.9593.
Surface characteristics and osteoblast cell functions were investigated for the nano-structured oxide layer on commercially pure titanium (CP-Ti) fabricated using microarc oxidation (MAO) and hydrothermal treatment (HT) methods. Ti-MAO-135HT, Ti-MAO-150HT, and Ti-MAO-175HT groups were fabricated by hydrothermally treating the MAO-treated specimens (Ti-MAO) in phosphorus-containing alkaline solution at temperatures of 135, 150, or 175 °C, respectively. After hydrothermal treatment, a nanosheet-shaped morphology, nano-needles and nanorods were observed on the porous surface of the Ti-MAO-135HT, Ti-MAO-150HT and Ti-MAO-175HT groups, respectively. The roughness was not significantly different for all groups. However the contact angle decreased dramatically as the hydrothermal temperature increased. The osteoblastic cell adhesion and viability of the Ti-MAO-150HT and Ti-MAO-175HT groups were significantly lower compared to those of the Ti-MAO group. This study showed that nano-topology formed on micro porous oxide layer was more important than hydrophilicity in its effect upon initial osteoblastic cell functions.
研究了采用微弧氧化（MAO）和水热处理（HT）方法制备的商业纯钛（CP-Ti）上纳米结构氧化层的表面特性和成骨细胞功能。Ti-MAO-135HT、Ti-MAO-150HT和Ti-MAO-175HT组分别通过在135、150或175°C的含磷碱性溶液中对微弧氧化处理后的试样（Ti-MAO）进行水热处理制备。水热处理后，在Ti-MAO-135HT、Ti-MAO-150HT和Ti-MAO-175HT组的多孔表面分别观察到纳米片状形态、纳米针和纳米棒。所有组的粗糙度无显著差异。然而，随着水热温度升高，接触角急剧下降。与Ti-MAO组相比，Ti-MAO-150HT和Ti-MAO-175HT组的成骨细胞黏附性和活力显著降低。本研究表明，在微孔氧化层上形成的纳米拓扑结构对初始成骨细胞功能的影响比亲水性更重要。
