Southern Crop Protection and Food Research Centre, Agriculture and Agri-Food Canada, London, Ontario, N5V 4T3, Canada; email:
Annu Rev Phytopathol. 2015;53:45-66. doi: 10.1146/annurev-phyto-080614-120001. Epub 2015 May 1.
A successful infection by a plant virus results from the complex molecular interplay between the host plant and the invading virus. Thus, dissecting the molecular network of virus-host interactions advances the understanding of the viral infection process and may assist in the development of novel antiviral strategies. In the past decade, molecular identification and functional characterization of host factors in the virus life cycle, particularly single-stranded, positive-sense RNA viruses, have been a research focus in plant virology. As a result, a number of host factors have been identified. These host factors are implicated in all the major steps of the infection process. Some host factors are diverted for the viral genome translation, some are recruited to improvise the viral replicase complexes for genome multiplication, and others are components of transport complexes for cell-to-cell spread via plasmodesmata and systemic movement through the phloem. This review summarizes current knowledge about host factors and discusses future research directions.
植物病毒的成功感染源于宿主植物和入侵病毒之间复杂的分子相互作用。因此，剖析病毒-宿主相互作用的分子网络可以增进对病毒感染过程的理解，并可能有助于开发新的抗病毒策略。在过去的十年中，植物病毒学的研究重点是鉴定和功能表征病毒生命周期中的宿主因子，特别是单链、正链 RNA 病毒。因此，已经鉴定出许多宿主因子。这些宿主因子涉及感染过程的所有主要步骤。一些宿主因子被病毒基因组翻译所利用，一些被招募来改进病毒复制酶复合物以进行基因组复制，还有一些是胞间连丝细胞间传播和韧皮部系统运动的运输复合物的组成部分。本文总结了目前关于宿主因子的知识，并讨论了未来的研究方向。
