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COX inhibition reduces vasodilator PGE2 but is shown to increase levels of chemoattractant 12-HETE in vivo in human sunburn.

作者信息

Pilkington Suzanne M, Murphy Sharon A, Kudva Shobha, Nicolaou Anna, Rhodes Lesley E

机构信息

Centre for Dermatology, Institute of Inflammation and Repair, University of Manchester, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.

Manchester Pharmacy School, Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK.

出版信息

Exp Dermatol. 2015 Oct;24(10):790-1. doi: 10.1111/exd.12734. Epub 2015 Jun 3.

DOI:10.1111/exd.12734
PMID:25939367
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4737235/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32d5/4737235/ffff69d0c938/EXD-24-790-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32d5/4737235/ffff69d0c938/EXD-24-790-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32d5/4737235/ffff69d0c938/EXD-24-790-g001.jpg

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COX inhibition reduces vasodilator PGE2 but is shown to increase levels of chemoattractant 12-HETE in vivo in human sunburn.环氧化酶（COX）抑制作用会降低血管舒张剂前列腺素E2（PGE2），但在人体晒伤的体内实验中显示会增加趋化因子12-羟基二十碳四烯酸（12-HETE）的水平。
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COX inhibition enhances inflammatory immune cell infiltration in UV-irradiated human skin: implications for the treatment of sunburn.环氧化酶（COX）抑制作用增强紫外线照射后人体皮肤中的炎性免疫细胞浸润：对晒伤治疗的启示
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Induction of cyclooxygenase-2 gene in pancreatic beta-cells by 12-lipoxygenase pathway product 12-hydroxyeicosatetraenoic acid.12-脂氧合酶途径产物12-羟基二十碳四烯酸对胰腺β细胞中环氧化酶-2基因的诱导作用。
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12-HETE is a regulator of PGE production via COX-2 expression induced by a snake venom group IIA phospholipase A in isolated peritoneal macrophages.12-HETE 通过蛇毒 IIA 组磷脂酶 A 诱导的 COX-2 表达来调节 PGE 的产生，这在分离的腹腔巨噬细胞中得到证实。
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Topical application of a selective cyclooxygenase inhibitor suppresses UVB mediated cutaneous inflammation.局部应用选择性环氧化酶抑制剂可抑制紫外线B介导的皮肤炎症。
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本文引用的文献

1
Eliminating or blocking 12/15-lipoxygenase reduces neutrophil recruitment in mouse models of acute lung injury.在急性肺损伤小鼠模型中，消除或阻断12/15-脂氧合酶可减少中性粒细胞募集。
Crit Care. 2012 Sep 13;16(5):R166. doi: 10.1186/cc11518.
2
Lipidomics of oxidized polyunsaturated fatty acids.氧化多不饱和脂肪酸的脂质组学
Free Radic Biol Med. 2013 Jun;59(100):45-55. doi: 10.1016/j.freeradbiomed.2012.08.565. Epub 2012 Aug 19.
3
The sunburn response in human skin is characterized by sequential eicosanoid profiles that may mediate its early and late phases.
人类皮肤的晒伤反应具有一系列类花生酸特征，这些特征可能介导其早期和晚期阶段。
FASEB J. 2009 Nov;23(11):3947-56. doi: 10.1096/fj.09-136077. Epub 2009 Jul 7.
4
Simultaneous lipidomic analysis of three families of bioactive lipid mediators leukotrienes, resolvins, protectins and related hydroxy-fatty acids by liquid chromatography/electrospray ionisation tandem mass spectrometry.通过液相色谱/电喷雾电离串联质谱法对生物活性脂质介质白三烯、消退素、保护素及相关羟基脂肪酸这三类物质进行同步脂质组学分析。
Rapid Commun Mass Spectrom. 2008;22(2):75-83. doi: 10.1002/rcm.3331.
5
Ultraviolet-B-induced erythema is mediated by nitric oxide and prostaglandin E2 in combination.紫外线B诱导的红斑是由一氧化氮和前列腺素E2共同介导的。
J Invest Dermatol. 2001 Oct;117(4):880-5. doi: 10.1046/j.0022-202x.2001.01514.x.
6
Cutaneous responses to 12-hydroxy-5,8,10,14-eicosatetraenoic acid (12-HETE).
J Invest Dermatol. 1985 Jun;84(6):537-41. doi: 10.1111/1523-1747.ep12273537.
7
12(R)-hydroxy-5,8,10,14-eicosatetraenoic acid is a chemoattractant for human polymorphonuclear leucocytes in vitro.12（R）-羟基-5,8,10,14-二十碳四烯酸在体外是人类多形核白细胞的一种趋化剂。
Prostaglandins. 1987 Jul;34(1):71-8. doi: 10.1016/0090-6980(87)90264-4.
8
Proinflammatory properties of unsaturated fatty acids and their monohydroxy metabolites.不饱和脂肪酸及其单羟基代谢产物的促炎特性。
Prostaglandins. 1985 Sep;30(3):497-509. doi: 10.1016/0090-6980(85)90122-4.
9
Indomethacin increases the formation of lipoxygenase products in calcium ionophore stimulated human neutrophils.吲哚美辛可增加钙离子载体刺激的人中性粒细胞中脂氧合酶产物的生成。
Biochem Biophys Res Commun. 1987 Oct 29;148(2):534-8. doi: 10.1016/0006-291x(87)90909-0.