Thomas Susan N, Rohner Nathan A, Edwards Erin E
George W. Woodruff School of Mechanical Engineering and.
Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332; email:
Annu Rev Biomed Eng. 2016 Jul 11;18:207-33. doi: 10.1146/annurev-bioeng-101515-014413. Epub 2016 Feb 24.
Adaptive immune response consists of many highly regulated, multistep cascades that protect against infection while preserving the health of autologous tissue. The proper initiation, maintenance, and resolution of such responses require the precise coordination of molecular and cellular signaling over multiple time and length scales orchestrated by lymphatic transport. In order to investigate these functions and manipulate them for therapy, a comprehensive understanding of how lymphatics influence immune physiology is needed. This review presents the current mechanistic understanding of the role of the lymphatic vasculature in regulating biomolecule and cellular transport from the interstitium, peripheral tissue immune surveillance, the lymph node stroma and microvasculature, and circulating lymphocyte homing to lymph nodes. This review also discusses the ramifications of lymphatic transport in immunity as well as tolerance and concludes with examples of how lymphatic-mediated targeting of lymph nodes has been exploited for immunotherapy applications.
适应性免疫反应由许多高度调控的多步骤级联反应组成，这些反应在保护机体免受感染的同时维持自体组织的健康。此类反应的正确启动、维持和消退需要在多个时间和长度尺度上通过淋巴转运精心协调分子和细胞信号传导。为了研究这些功能并对其进行治疗性操控，需要全面了解淋巴管如何影响免疫生理学。本综述介绍了目前对淋巴管系统在调节间质中生物分子和细胞转运、外周组织免疫监视、淋巴结基质和微血管以及循环淋巴细胞归巢至淋巴结方面作用的机制理解。本综述还讨论了淋巴转运在免疫以及耐受性方面的影响，并以淋巴介导的淋巴结靶向在免疫治疗应用中的实例作为结尾。
