Schmitt Jochen, Küster Denise
Medical Faculty Carl Gustav Carus, Centre for Evidence-Based Healthcare, Technische Universität Dresden, Fetscherstr. 74, 01307, Dresden, Germany.
Arch Dermatol Res. 2015 Jul;307(5):451-3. doi: 10.1007/s00403-015-1567-x. Epub 2015 May 5.
Data on indirect costs are vital for cost-effectiveness studies from a societal perspective. In contrast to quality of life, information on productivity loss is rarely collected in psoriasis trials. We aimed to identify a model to deduce indirect costs (presenteeism and absenteeism) of psoriasis from the Dermatologic Life Quality Index (DLQI) of affected patients to facilitate health economic evaluations for psoriasis. We undertook a cross-sectional mapping study including 201 patients with physician-diagnosed psoriasis and investigated the relationship between quality of life (DLQI) and productivity loss (Work Limitations Questionnaire, WLQ--using the "output demands" subscale) using linear bootstrap regression analysis to set up an equation model allowing the calculation of percent work productivity loss per DLQI unit increase. DLQI and WLQ scores were significantly correlated (r = 0.47; p < 0.0001) The final equation model suggests a 0.545 and 0.560% decrease in productivity due to presenteeism and absenteeism per DLQI unit increase, with y-intercepts at 1.654 and 0.536, respectively. In the absence of data on indirect cost, work productivity loss due to psoriasis can be estimated from DLQI scores using the equations, Y = 0.545 × DLQI score + 1.654 for presenteeism (%) and Y = 0.560 × DLQI score + 0.536 for absenteeism (%).
从社会角度来看，间接成本数据对于成本效益研究至关重要。与生活质量不同，银屑病试验中很少收集生产率损失方面的信息。我们旨在确定一种模型，以便根据受影响患者的皮肤病生活质量指数（DLQI）推断银屑病的间接成本（出勤主义和旷工），从而促进银屑病的卫生经济评估。我们进行了一项横断面映射研究，纳入了201例经医生诊断为银屑病的患者，并使用线性自举回归分析研究生活质量（DLQI）与生产率损失（工作限制问卷，WLQ——使用“产出需求”子量表）之间的关系，以建立一个方程模型，该模型能够计算每增加一个DLQI单位时工作生产率损失的百分比。DLQI和WLQ得分显著相关（r = 0.47；p < 0.0001）。最终的方程模型表明，每增加一个DLQI单位，由于出勤主义和旷工导致的生产率分别下降0.545%和0.560%，截距分别为1.654和0.536。在缺乏间接成本数据的情况下，可以使用方程Y = 0.545×DLQI得分 + 1.654（用于计算出勤主义导致的生产率损失百分比）和Y = 0.560×DLQI得分 + 0.536（用于计算旷工导致的生产率损失百分比），根据DLQI得分估算银屑病导致的工作生产率损失。
