Hussen Hozan I, Persson Martina, Moradi Tahereh
Department of Environmental Medicine, Division of Epidemiology, Unit of Cardiovascular Epidemiology, Karolinska Institutet, Nobels väg 13, Box 210, SE-171 77, Stockholm, Sweden.
Diabetologia. 2015 Jul;58(7):1464-73. doi: 10.1007/s00125-015-3580-1. Epub 2015 May 6.
AIMS/HYPOTHESIS: The incidence of type 1 diabetes in children is increasing in Sweden, as is the prevalence of maternal overweight/obesity. Therefore, the aim of this study was to investigate if maternal overweight/obesity increases the risk of type 1 diabetes in offspring of parents with and without diabetes, and of different ethnicities.
The study cohort comprised 1,263,358 children, born in Sweden between 1992 and 2004. Children were followed from birth until diagnosis of type 1 diabetes, emigration, death or end of follow-up in 2009, whichever occurred first. First trimester maternal BMI was calculated (kg/m(2)). Poisson regression was used to calculate incidence rate ratios (IRRs) with 95% CI for type 1 diabetes in the offspring.
The risk of type 1 diabetes was increased in offspring of parents with any type of diabetes regardless of parental ethnicity. High first trimester maternal BMI was associated with increased risk of type 1 diabetes only in offspring of parents without diabetes (IRR 1.33 [95% CI 1.20, 1.48]).
CONCLUSIONS/INTERPRETATION: Increasing incidence of type 1 diabetes in children with non-diabetic parents may partly be explained by increasing prevalence of maternal overweight/obesity.
目的/假设：在瑞典，儿童1型糖尿病的发病率以及母亲超重/肥胖的患病率均在上升。因此，本研究旨在调查母亲超重/肥胖是否会增加父母患糖尿病及不同种族的后代患1型糖尿病的风险。
研究队列包括1992年至2004年在瑞典出生的1,263,358名儿童。对儿童从出生开始进行随访，直至其被诊断为1型糖尿病、移民、死亡或2009年随访结束，以先发生者为准。计算孕早期母亲的体重指数（kg/m²）。采用泊松回归计算后代患1型糖尿病的发病率比（IRR）及95%置信区间。
无论父母种族如何，患有任何类型糖尿病的父母的后代患1型糖尿病的风险都会增加。孕早期母亲体重指数较高仅与无糖尿病父母的后代患1型糖尿病的风险增加有关（发病率比1.33 [95%置信区间1.20, 1.48]）。
结论/解读：非糖尿病父母的子女中1型糖尿病发病率上升，部分原因可能是母亲超重/肥胖患病率增加。
