a Nitte University Centre for Science Education and Research (NUCSER), NITTE (Deemed to be University) , Paneer Campus, Deralakatte, Mangalore , Karnataka , India.
Crit Rev Food Sci Nutr. 2019;59(15):2363-2374. doi: 10.1080/10408398.2018.1452182. Epub 2018 Apr 5.
The rising interest to utilize nutritionally exorbitant fish proteins has instigated research activities in fish waste utilization. The development of newer technologies to utilize fish waste has fostered use of bioactive value-added products for specific health benefits. Enzymatically obtained Fish Protein Hydrolysate (FPH) is a rich source of biologically active peptides possessing anti-oxidant, anticancer, antimicrobial and anti-hypertensive activity. Isolating natural remedies to combat alarming negative consequences of synthetic drugs has been the new trend in current research promoting identification of antihypertensive peptides from FPH. In this review, we aim to culminate data available to produce antihypertensive peptides from FPH, its composition and potential to be used as a therapeutic agent. These purified peptides are known to be rich in arginine, valine and leucine. Reports reveal peptides with low molecular weight (<1 kDa) and shorter chain length (<20 amino acids) exhibited higher antihypertensive activity. As these peptides have proven Angiotensin Converting Enzyme - I inhibitory activity and , their potential to be used as antihypertensive drugs is outrageous. However, current focus on research in the field of molecular docking is necessary to have improved understanding of interaction of the peptides with the enzyme.
人们对利用营养价值过高的鱼类蛋白的兴趣日益浓厚，这促使人们开展了鱼类废物利用的研究活动。新技术的发展促进了利用鱼废弃物生产具有特定保健功能的生物活性增值产品。酶法获得的鱼蛋白水解物（Fish Protein Hydrolysate，FPH）是一种富含生物活性肽的丰富来源，具有抗氧化、抗癌、抗菌和抗高血压活性。从合成药物令人震惊的负面后果中寻找天然疗法一直是当前研究的新趋势，这一趋势推动了从 FPH 中鉴定具有降血压作用的肽。在这篇综述中，我们旨在汇总现有的数据，以生产 FPH 的降血压肽，及其组成和作为治疗剂的潜力。这些已被纯化的肽富含精氨酸、缬氨酸和亮氨酸。有报道称，分子量较小（<1 kDa）和链长较短（<20 个氨基酸）的肽具有更高的降血压活性。由于这些肽已被证明具有血管紧张素转化酶-I 抑制活性，因此它们有可能被用作抗高血压药物。然而，目前有必要对分子对接领域的研究进行重点关注，以提高对这些肽与酶相互作用的理解。
