Eleuterio Nibia Mariana, Palei Ana C T, Rangel Machado Jackeline S, Tanus-Santos Jose E, Cavalli Ricardo C, Sandrim Valeria C
Department of Pharmacology, Institute of Biosciences, Universidade Estadual Paulista (UNESP), Botucatu/SP, Brazil.
Department of Pharmacology, Faculty of Medicinal Sciences, University of Campinas, State University of Campinas, Campinas/SP, Brazil.
Pregnancy Hypertens. 2015 Apr;5(2):205-8. doi: 10.1016/j.preghy.2015.03.001. Epub 2015 Mar 21.
The aims of the present study were to compare plasma concentrations of the adiponectin, leptin, metalloproteinases (MMP9 and MMP2) and its tissue inhibitors (TIMP1 and TIMP2) in preeclamptic (PE) and healthy pregnant (HP) groups and correlate them.
A total of 105 pregnant women with pre-pregnancy body mass index (BMI) values ⩽ 30 kg/m(2) were enrolled for this study (59 PE and 46 HP). Biomarkers were measured using ELISAs.
Adiponectin (32%), leptin (45%), MMP2 (20%), TIMP1 (31%) and TIMP2 (23%) levels were higher in PE compared to HP (all P < 0.05). In addition there were positive correlations between adiponectin and MMP2 (r = 0.33; P = 0.03) and adiponectin and TIMP2 (r = 0.33; P = 0.03) in PE group, but not in HP.
Our findings show that adiponectin, leptin, MMP2, TIMP1 and TIMP2 levels are increased in PE and adiponectin may contribute to higher levels of MMP2 and TIMP2 in this disease.
本研究旨在比较子痫前期（PE）组和健康妊娠（HP）组中脂联素、瘦素、金属蛋白酶（MMP9和MMP2）及其组织抑制剂（TIMP1和TIMP2）的血浆浓度，并对它们进行相关性分析。
本研究共纳入105例孕前体重指数（BMI）值≤30kg/m²的孕妇（59例PE组和46例HP组）。使用酶联免疫吸附测定法（ELISA）检测生物标志物。
与HP组相比，PE组中脂联素（32%）、瘦素（45%）、MMP2（20%）、TIMP1（31%）和TIMP2（23%）水平更高（所有P<0.05）。此外，PE组中脂联素与MMP2之间存在正相关（r=0.33；P=0.03），脂联素与TIMP2之间也存在正相关（r=0.33；P=0.03），而HP组中不存在这种相关性。
我们的研究结果表明，PE组中脂联素、瘦素、MMP2、TIMP1和TIMP2水平升高，脂联素可能导致该疾病中MMP2和TIMP2水平升高。
