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多重耐药性纹带棒状杆菌生物膜形成与医院感染暴发相关

Biofilm production by multiresistant Corynebacterium striatum associated with nosocomial outbreak.

作者信息

Souza Cassius de, Faria Yuri Vieira, Sant'Anna Lincoln de Oliveira, Viana Vanilda Gonçalves, Seabra Sérgio Henrique, Souza Mônica Cristina de, Vieira Verônica Viana, Hirata Júnior Raphael, Moreira Lílian de Oliveira, Mattos-Guaraldi Ana Luíza de

机构信息

Laboratório de Difteria e Corinebactérias de Importância Clínica, Centro Colaborador de Referência e Pesquisa em Difteria/Fundação Nacional de Saúde/Ministério da Saúde, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.

Laboratório de Tecnologia em Bioquímica e Microscopia, Centro Universitário Estadual da Zona Oeste, Rio de Janeiro, RJ, Brasil.

出版信息

Mem Inst Oswaldo Cruz. 2015 Apr;110(2):242-8. doi: 10.1590/0074-02760140373.

DOI:10.1590/0074-02760140373
PMID:25946249
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4489456/
Abstract

Corynebacterium striatum is a potentially pathogenic microorganism that causes nosocomial outbreaks. However, little is known about its virulence factors that may contribute to healthcare-associated infections (HAIs). We investigated the biofilm production on abiotic surfaces of multidrug-resistant (MDR) and multidrug-susceptible (MDS) strains of C. striatum of pulsed-field gel electrophoresis types I-MDR, II-MDR, III-MDS and IV-MDS isolated during a nosocomial outbreak in Rio de Janeiro, Brazil. The results showed that C. striatum was able to adhere to hydrophilic and hydrophobic abiotic surfaces. The C. striatum 1987/I-MDR strain, predominantly isolated from patients undergoing endotracheal intubation procedures, showed the greatest ability to adhere to all surfaces. C. striatum bound fibrinogen to its surface, which contributed to biofilm formation. Scanning electron microscopy showed the production of mature biofilms on polyurethane catheters by all pulsotypes. In conclusion, biofilm production may contribute to the establishment of HAIs caused by C. striatum.

摘要

纹带棒状杆菌是一种可引发医院感染暴发的潜在致病微生物。然而，对于其可能导致医疗保健相关感染（HAIs）的毒力因子，我们知之甚少。我们调查了在巴西里约热内卢一次医院感染暴发期间分离出的脉冲场凝胶电泳I-MDR型、II-MDR型、III-MDS型和IV-MDS型的纹带棒状杆菌的多药耐药（MDR）和多药敏感（MDS）菌株在非生物表面上的生物膜形成情况。结果表明，纹带棒状杆菌能够附着在亲水性和疏水性非生物表面上。主要从接受气管插管手术的患者中分离出的纹带棒状杆菌1987/I-MDR菌株，显示出对所有表面的最强附着能力。纹带棒状杆菌将纤维蛋白原结合到其表面，这有助于生物膜的形成。扫描电子显微镜显示所有脉冲型在聚氨酯导管上都产生了成熟的生物膜。总之，生物膜的形成可能有助于由纹带棒状杆菌引起的HAIs的发生。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b28/4489456/692f42294648/0074-0276-mioc-110-2-0242-gf04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b28/4489456/794b96e67ff9/0074-0276-mioc-110-2-0242-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b28/4489456/0ddf1c109bff/0074-0276-mioc-110-2-0242-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b28/4489456/49959a58ba35/0074-0276-mioc-110-2-0242-gf03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b28/4489456/692f42294648/0074-0276-mioc-110-2-0242-gf04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b28/4489456/794b96e67ff9/0074-0276-mioc-110-2-0242-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b28/4489456/0ddf1c109bff/0074-0276-mioc-110-2-0242-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b28/4489456/49959a58ba35/0074-0276-mioc-110-2-0242-gf03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b28/4489456/692f42294648/0074-0276-mioc-110-2-0242-gf04.jpg

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