巴西里约热内卢医院环境中的克隆性多药耐药棒状杆菌。
Clonal multidrug-resistant Corynebacterium striatum within a nosocomial environment, Rio de Janeiro, Brazil.
机构信息
Laboratório de Difteria e Corinebactérias de Importância Clínica, Departamento de Microbiologia, Imunologia e Patologia, Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
出版信息
Mem Inst Oswaldo Cruz. 2013 Feb;108(1):23-9. doi: 10.1590/s0074-02762013000100004.
Corynebacterium striatum is a potentially pathogenic microorganism with the ability to produce outbreaks of nosocomial infections. Here, we document a nosocomial outbreak caused by multidrug-resistant (MDR) C. striatum in Rio de Janeiro, Brazil. C. striatum identification was confirmed by 16S rRNA and rpoB gene sequencing. Fifteen C. striatum strains were isolated from adults (half of whom were 50 years of age and older). C. striatum was mostly isolated in pure culture from tracheal aspirates of patients undergoing endotracheal intubation procedures. The analysis by pulsed-field gel electrophoresis (PFGE) indicated the presence of four PFGE profiles, including two related clones of MDR strains (PFGE I and II). The data demonstrated the predominance of PFGE type I, comprising 11 MDR isolates that were mostly isolated from intensive care units and surgical wards. A potential causal link between death and MDR C. striatum (PFGE types I and II) infection was observed in five cases.
棒状杆菌是一种具有引起医院感染暴发能力的潜在病原微生物。在这里，我们记录了巴西里约热内卢一起由耐多药棒状杆菌引起的医院感染暴发事件。棒状杆菌的鉴定通过 16S rRNA 和 rpoB 基因测序得到确认。从成人（其中一半年龄在 50 岁及以上）中分离出了 15 株棒状杆菌。棒状杆菌主要从接受气管插管程序的患者的气管吸出物中以纯培养的方式分离出来。脉冲场凝胶电泳（PFGE）分析表明存在四种 PFGE 图谱，包括两种相关的耐多药菌株克隆（PFGE I 和 II）。数据表明 PFGE 类型 I 占主导地位，包括 11 株耐多药分离株，主要从重症监护病房和外科病房中分离出来。在五例死亡病例中观察到与耐多药棒状杆菌（PFGE 类型 I 和 II）感染之间存在潜在的因果关系。
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