Toll样受体9（TLR9）基因多态性与肺结核风险的关联：荟萃分析

Association between toll-like receptors 9 (TLR9) gene polymorphism and risk of pulmonary tuberculosis: meta-analysis.

作者信息

Chen Zhi, Wang Wei, Liang Jianqin, Wang Jinhe, Feng Shisheng, Zhang Guangyu

机构信息

Department of Tuberculosis, The 309th hospital of PLA, No. 17, Heishanhu Road, Haidian District, Beijing, 100091, China.

出版信息

BMC Pulm Med. 2015 May 8;15:57. doi: 10.1186/s12890-015-0049-4.

BACKGROUND

Previous studies indicated that the single nucleotide polymorphisms (SNPs) in TLR9 gene might be associated with Tuberculosis (TB) risk. However, the results are inconsistent and inconclusive.

METHODS

1745 articles from four databases were involved in our study. A meta-analysis on the associations between the seven polymorphisms and TB risk was carried out by comparison using different genetic models.

RESULTS

In this systematic review 8 studies from seven English articles were analyzed. Our results showed that rs352139 is significantly associated with TB risk (AA vs. AG, OR 0.77, 95% CI 0.65-0.92, P = 0.004). In the ethnic subgroup analysis, Indonesians with AA genotype had a decreased susceptibility while Mexicans with GG allele had an increased risk.

CONCLUSIONS

The meta-analysis indicated that rs352139 polymorphism might be associated with decreased TB risk in Indonesians whereas increased risk in Mexicans. Whether the observed association was due to causal effect needs to be further studied.

背景

先前的研究表明，Toll样受体9（TLR9）基因中的单核苷酸多态性（SNP）可能与结核病（TB）风险相关。然而，结果并不一致且尚无定论。

方法

我们的研究纳入了来自四个数据库的1745篇文章。通过使用不同的遗传模型进行比较，对七种多态性与结核病风险之间的关联进行了荟萃分析。

结果

在本系统评价中，分析了七篇英文文章中的8项研究。我们的结果表明，rs352139与结核病风险显著相关（AA与AG相比，比值比[OR]为0.77，95%置信区间[CI]为0.65 - 0.92，P = 0.004）。在种族亚组分析中，AA基因型的印度尼西亚人易感性降低，而携带GG等位基因的墨西哥人风险增加。