Penston J, Wormsley K G
Ninewells Hospital, Dundee, Scotland, U.K.
Scand J Gastroenterol. 1989 Nov;24(9):1145-52. doi: 10.3109/00365528909089269.
The efficacy and safety of continuous (maintenance) treatment with ranitidine has been studied retrospectively in 388 patients with duodenal ulcer. The cumulative rate of symptomatic relapse was 16% after 5 years. Very few of the patients developed ulcer complications during maintenance treatment, with a cumulative risk of haemorrhage of 1.8% during 5 years. The patients developed no drug-related disease. We conclude that long-term, continuous treatment with ranitidine is effective in maintaining remission of duodenal ulcers, protects the patients against the risk of complications, and is safe.
对388例十二指肠溃疡患者进行了回顾性研究，以评估雷尼替丁持续（维持）治疗的疗效和安全性。5年后症状复发的累积率为16%。在维持治疗期间，很少有患者出现溃疡并发症，5年内出血的累积风险为1.8%。患者未出现与药物相关的疾病。我们得出结论，雷尼替丁长期持续治疗对维持十二指肠溃疡缓解有效，可保护患者免受并发症风险，且安全。
