Mandelia Chetan, Sreedharan Suja
PGY-1 Pediatrics, University of Texas Medical Branch Hospitals , Galveston, Texas, USA .
PGY-1 Pediatrics, Cleveland Clinic Children's Hospital , Cleveland, Ohio, USA .
J Clin Diagn Res. 2015 Mar;9(3):MC05-8. doi: 10.7860/JCDR/2015/9630.5702. Epub 2015 Mar 1.
With changed clinical profile of HIV related diseases, our study attempted to analyse otorhinolaryngological manifestations in HIV positive children coming to ART centre of a tertiary referral in South India.
Records of 137 children registered at ART Centre, Government Wenlock Hospital, Kasturba Medical College, Mangalore from 2004 till 2010 were studied and data for this retrospective study was collected.
Twenty three (16.8%) children developed otorhinolaryngological manifestations, which were upper respiratory tract infection (13.1%), oral candidiasis (1.4%), otitis media (1.4%) and parotitis (1%). With increasing WHO stage, the ENT manifestations increased (p<0.05) while CD4 count decreased (p>0.05), 35% and 44% cases with ENT manifestations had CD4 counts above 500 cells/mm3 and below 200 cells/mm3 respectively (p>0.05). 24% children on HAART and 10.7% not on HAART developed ENT illnesses (p<0.05).
With the current ART protocols, ENT manifestations are seen in 17% HIV positive children, most of which are aspecific.
随着与HIV相关疾病临床特征的变化，我们的研究试图分析在印度南部一家三级转诊机构的抗逆转录病毒治疗中心就诊的HIV阳性儿童的耳鼻喉科表现。
研究了2004年至2010年在芒格洛尔卡斯图尔巴医学院政府温洛克医院抗逆转录病毒治疗中心登记的137名儿童的记录，并收集了这项回顾性研究的数据。
23名（16.8%）儿童出现耳鼻喉科表现，其中上呼吸道感染（13.1%）、口腔念珠菌病（1.4%）、中耳炎（1.4%）和腮腺炎（1%）。随着世界卫生组织分期的增加，耳鼻喉科表现增加（p<0.05），而CD4细胞计数下降（p>0.05），有耳鼻喉科表现的病例中分别有35%和44%的CD4细胞计数高于500个细胞/mm3和低于200个细胞/mm3（p>0.05）。接受高效抗逆转录病毒治疗的儿童中有24%出现耳鼻喉科疾病，未接受治疗的儿童中有10.7%出现耳鼻喉科疾病（p<0.05）。
按照目前的抗逆转录病毒治疗方案，17%的HIV阳性儿童出现耳鼻喉科表现，其中大多数不具有特异性。
