Stein M, Bartal A, Kuten A, Loberant N, Hershkovitz R, Masalcha H, Robinson E
Northern Israel Oncology Center, Rambam Medical Center, Haifa.
S Afr Med J. 1989 Dec 16;76(12):664-6.
The occurrence of breast and thyroid multiple primary neoplasms has been evaluated using data from the Israel Cancer Registry. During the 16 years 1960-1976, 3,072 cases of thyroid cancer were registered in Israel. The occurrence of a second primary tumour was reported in 92 of these patients. In this latter group were 25 female patients (27%) with breast cancer, developing synchronously in 7 cases and metachronously in the remaining 18. The average age at the time of appearance of breast cancer was 50 years. Most of the patients (84%) were of European origin. The most common histological types were ductal and intraductal carcinoma and scirrhous adenocarcinoma. The possible aetiological factors common to breast and thyroid cancer are discussed. Efforts aimed at improving the survival of patients with thyroid cancer must incorporate strategies for the early detection and treatment of secondary breast cancer.
利用以色列癌症登记处的数据，对乳腺和甲状腺多原发性肿瘤的发生情况进行了评估。在1960年至1976年的16年间，以色列共登记了3072例甲状腺癌病例。其中92例患者报告发生了第二原发性肿瘤。在后一组中有25例女性乳腺癌患者（占27%），其中7例为同时发生，其余18例为异时发生。乳腺癌出现时的平均年龄为50岁。大多数患者（84%）来自欧洲。最常见的组织学类型是导管癌、导管内癌和硬癌性腺癌。文中讨论了乳腺癌和甲状腺癌共有的可能病因因素。旨在提高甲状腺癌患者生存率的努力必须纳入早期发现和治疗继发性乳腺癌的策略。
