De La Cruz Enrique M, Gardel Margaret L
From the Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06511 and
the Institute for Biophysical Dynamics, James Franck Institute, and Department of Physics, University of Chicago, Chicago, Illinois 60637
J Biol Chem. 2015 Jul 10;290(28):17137-44. doi: 10.1074/jbc.R115.636472. Epub 2015 May 8.
Cell physiological processes require the regulation and coordination of both mechanical and dynamical properties of the actin cytoskeleton. Here we review recent advances in understanding the mechanical properties and stability of actin filaments and how these properties are manifested at larger (network) length scales. We discuss how forces can influence local biochemical interactions, resulting in the formation of mechanically sensitive dynamic steady states. Understanding the regulation of such force-activated chemistries and dynamic steady states reflects an important challenge for future work that will provide valuable insights as to how the actin cytoskeleton engenders mechanoresponsiveness of living cells.
细胞生理过程需要对肌动蛋白细胞骨架的机械和动力学特性进行调节与协调。在此，我们综述了在理解肌动蛋白丝的机械特性和稳定性以及这些特性如何在更大（网络）长度尺度上表现方面的最新进展。我们讨论了力如何影响局部生化相互作用，从而导致形成机械敏感的动态稳态。理解这种力激活化学和动态稳态的调节是未来工作的一项重要挑战，这将为肌动蛋白细胞骨架如何赋予活细胞机械反应性提供有价值的见解。
