Wang Weiwen, Deng Huihua, Wang Li, Cao Chengqi, Xu Hang, Zhang Jianxin
Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
Research Center for Learning Science, Southeast University, Nanjing, China.
J Affect Disord. 2015 Aug 15;182:18-22. doi: 10.1016/j.jad.2015.04.036. Epub 2015 Apr 29.
Cortisone has been proposed as a useful additional biomarker for stress research. However, only very limited studies has investigated alterations of cortisone levels in stress-related mental disorder such as PTSD. The present study investigated the associations between PTSD symptomatology and hair cortisone levels which can reflect cumulative cortisone secretion over prolonged periods of time and is more robust to the influence of situational confounding.
Participants included 201 females who experienced 2008 Wenchuan earthquake and lost their children during the disaster. PTSD symptoms were assessed with the PTSD Checklist (PCL), and depression symptoms with the Center for epidemiological studies depression scale (CES-D). Hair cortisone levels were quantified by liquid chromatography tandem mass spectrometer.
The results indicated that although hair cortisone secretion could not distinguish traumatized individuals with and without PTSD, it was uniquely linked to dysphoric arousal symptoms, a key aspect of the complex PTSD phenotype
A sample of females exposed to specific traumatic events was used, and PTSD was assessed using a self-reported measure.
The findings provide preliminary evidence supporting the critical role of long-term cortisone changes in the development and maintenance of PTSD symptoms, and add to extant knowledge on the neuroendocrinological underpinnings of posttraumatic psychopathology.
可的松已被提议作为应激研究中一种有用的额外生物标志物。然而，仅有非常有限的研究调查了诸如创伤后应激障碍（PTSD）等应激相关精神障碍中可的松水平的变化。本研究调查了PTSD症状与头发可的松水平之间的关联，头发可的松水平能够反映长时间内累积的可的松分泌情况，并且对情境混杂因素的影响更具稳健性。
参与者包括201名在2008年汶川地震中经历丧子之痛的女性。使用PTSD检查表（PCL）评估PTSD症状，使用流行病学研究中心抑郁量表（CES-D）评估抑郁症状。通过液相色谱串联质谱仪对头发中的可的松水平进行定量。
结果表明，尽管头发可的松分泌无法区分患有和未患有PTSD的受创伤个体，但它与烦躁性觉醒症状存在独特关联，而烦躁性觉醒症状是复杂PTSD表型的一个关键方面。
使用了暴露于特定创伤事件的女性样本，并且使用自我报告测量方法评估PTSD。
这些发现提供了初步证据，支持长期可的松变化在PTSD症状的发生和维持中起关键作用，并增加了关于创伤后精神病理学神经内分泌基础的现有知识。
