Cruse Glenn, Bradding Peter
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, Glenfield Hospital, Leicester LE3 9QP, UK.
Eur J Pharmacol. 2016 May 5;778:125-38. doi: 10.1016/j.ejphar.2015.04.046. Epub 2015 May 8.
Mast cells are major effector cells of inflammation and there is strong evidence that mast cells play a significant role in asthma pathophysiology. There is also a growing body of evidence that mast cells contribute to other inflammatory and fibrotic lung diseases such as chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis. This review discusses the role that mast cells play in airway diseases and highlights how mast cell microlocalisation within specific lung compartments and their cellular interactions are likely to be critical for their effector function in disease.
肥大细胞是炎症的主要效应细胞，有充分证据表明肥大细胞在哮喘病理生理学中起重要作用。也有越来越多的证据表明肥大细胞与其他炎症性和纤维化肺部疾病有关，如慢性阻塞性肺疾病和特发性肺纤维化。这篇综述讨论了肥大细胞在气道疾病中的作用，并强调肥大细胞在特定肺区室中的微定位及其细胞间相互作用可能对其在疾病中的效应功能至关重要。
