雌激素抑制褪黑素增强的仓鼠精子过度激活。
Estrogen suppresses melatonin-enhanced hyperactivation of hamster spermatozoa.
作者信息
Fujinoki Masakatsu, Takei Gen L
机构信息
Department of Physiology, Dokkyo Medical University, Tochigi 321-0293, Japan.
出版信息
J Reprod Dev. 2015;61(4):287-95. doi: 10.1262/jrd.2014-116. Epub 2015 May 11.
Hamster sperm hyperactivation is enhanced by progesterone, and this progesterone-enhanced hyperactivation is suppressed by 17β-estradiol (17βE2) and γ-aminobutyric acid (GABA). Although it has been indicated that melatonin also enhances hyperactivation, it is unknown whether melatonin-enhanced hyperactivation is also suppressed by 17βE2 and GABA. In the present study, melatonin-enhanced hyperactivation was significantly suppressed by 17βE2 but not by GABA. Moreover, suppression of melatonin-enhanced hyperactivation by 17βE2 occurred through non-genomic regulation via the estrogen receptor (ER). These results suggest that enhancement of hyperactivation is regulated by melatonin and 17βE2 through non-genomic regulation.
孕酮可增强仓鼠精子的超激活作用，而这种由孕酮增强的超激活作用会受到17β-雌二醇（17βE2）和γ-氨基丁酸（GABA）的抑制。尽管已有研究表明褪黑素也能增强超激活作用，但褪黑素增强的超激活作用是否也会受到17βE2和GABA的抑制尚不清楚。在本研究中，17βE2可显著抑制褪黑素增强的超激活作用，而GABA则无此作用。此外，17βE2对褪黑素增强的超激活作用的抑制是通过雌激素受体（ER）的非基因组调控实现的。这些结果表明，超激活作用的增强是由褪黑素和17βE2通过非基因组调控来调节的。
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